MUC1 and ERBB2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MUC1	ERBB2
Description		mucin 1, cell surface associated	erb-b2 receptor tyrosine kinase 2
Image
GO Annotations	Cellular Component	Chromatin Extracellular Space Nucleus Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Vesicle Extracellular Exosome	Nucleus Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane ERBB3:ERBB2 Complex Myelin Sheath Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding P53 Binding Transcription Coregulator Activity Protein Binding	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Transcription By Competitive Promoter Binding O-glycan Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuron Differentiation Positive Regulation Of Cell Growth Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Kinase Activity Intracellular Signal Transduction ERBB2 Signaling Pathway Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of ERBB Signaling Pathway Regulation Of Cell Motility
Pathways		Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family Interleukin-4 and Interleukin-13 signaling O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Signaling by ERBB2 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D induced cell migration and growth-cone collapse RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		TG4010	Trastuzumab Lapatinib IGN311 Trastuzumab emtansine Varlitinib AV-412 Pertuzumab Afatinib Tucatinib Tesevatinib Fostamatinib Brigatinib Margetuximab Zanubrutinib
Diseases			Choriocarcinoma Pancreatic cancer Gastric cancer Bladder cancer Endometrial Cancer Ovarian cancer Cholangiocarcinoma Breast cancer Cervical cancer
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Estimated glomerular filtration rate ( 31015462) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric cancer ( 26098866 26129866 31383772) Gout ( 31578528) Inflammatory bowel disease ( 28067908) Magnesium levels ( 20700443 25886283 26058915) Non-cardia gastric cancer ( 26701879) Serum magnesium levels ( 29093028) Serum uric acid levels ( 30993211 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Adult asthma ( 30787307) Asthma ( 31619474 29273806) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 27329760) Estimated glomerular filtration rate ( 31451708) Pancreatic ductal adenocarcinoma ( 30541042) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Ulcerative colitis ( 20228799)
Interacting Genes		134 interacting genes: ABL1 ADAM33 ADGRB3 ADIPOQ ANKRD46 APC APOA2 APP AQP1 AQP2 AQP3 ARV1 BCL2L2 BMI1 BRICD5 BTN2A2 C14orf180 C1GALT1 C2 C2CD2L C3orf52 CACNG1 CCDC167 CD47 CD53 CD68 CLDN19 CLDN6 CLDND2 CMTM7 COL8A2 CSGALNACT2 CTNNB1 CTNND1 CTSA CXCL16 CXCL9 CYB5B CYP4F2 EDDM3B EGFR EMC6 EMP3 ENTPD3 ERBB2 ERBB3 ERBB4 ERG28 ESR1 EZH2 GALNT1 GALNT10 GALNT12 GALNT15 GALNT2 GALNT4 GAST GDNF GOLT1B GPR108 GRB2 GSK3B HHATL HSP90AA1 HSPA4 ICMT INSIG2 ITGAM JUP LCK LYN MAL2 MALL MARCHF2 MFSD5 MIP MYADM NDUFA3 NEU1 NINJ1 NINJ2 NKG7 NUP62 OR10AG1 OSGEP PAQR6 PLN PLP1 PLPP6 PNLIPRP1 PPARG PPIF PRKCD RFT1 RHD SCAMP5 SELENOK SERP2 SFTPC SIGLEC1 SLC22A1 SLC30A8 SLC35B4 SLC35E4 SLC38A7 SMCO4 SMIM1 SOS1 SRC TECR THBD TM6SF2 TMEM11 TMEM120B TMEM121 TMEM128 TMEM147 TMEM14A TMEM14C TMEM187 TMEM229B TMEM243 TMEM86A TMEM86B TMEM97 TMEM98 TNFRSF10B TP53 TRAM1L1 UNC50 VAMP5 VKORC1 ZAP70 ZDHHC21	350 interacting genes: AATK ABCB5 ABL1 ABL2 ACP1 ACP3 ADGRB1 AIP AKAP12 AKT1 ALDOA ALDOC ALK ANKS1A ANKS1B ANXA6 AP3B2 APBB1 APBB3 APLP1 ARF1 ARF5 ARNT ASRGL1 ATP6AP1 ATP6V0C AURKA BAAT BCAR3 BECN1 BLK BLNK BMX BNIP1 BTC CACYBP CALM1 CAV1 CBLC CBR1 CCDC180 CCND2 CCT3 CD44 CD82 CDK4 CDK6 CDK8 CDKN2B CDKN2C CEND1 CFAP298 CFL1 CHN1 CISH CKB CLASP2 CLCN6 CLNK COL9A2 COL9A3 CRIP2 CRK CRKL CSDE1 CTNNB1 CXCL8 CYLC2 CYP17A1 DAB1 DDR1 DLG4 DOK1 DOK4 DOK6 DST DUSP14 DUSP18 DUSP19 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHB1 EPHB2 EPHB3 EPHB6 ERBB3 ERBB4 ERBIN ERG28 ERRFI1 ESR1 FAM241B FBP1 FBXO7 FER FES FGFR1 FGFR2 FGFR3 FGFR4 FGR FKBP1A FKBP3 FKBP8 FLNB FLT3 FLT4 FRAT2 FZR1 GAB1 GABARAPL1 GABARAPL2 GAPDH GLCE GLIS2 GLRX3 GMPR2 GPM6B GRAP2 GRB10 GRB14 GRB2 GRB7 GRK2 GRM1 GSN HCK HDAC6 HDLBP HGF HLA-A HRAS HSD17B3 HSH2D HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA9 HSPD1 IARS1 IGF1R IL13RA2 IL6ST ILF3 ILKAP INPPL1 INSR INSRR IRF2BP2 IRS1 IRS4 ITGA5 ITGB4 ITK ITPKA ITPR1 JAK1 JAK2 JMJD4 JUP KCTD6 KDELR2 KLC1 KLK5 LATS2 LCK LCP2 LGALS8 LPCAT4 LRRC7 LYN LYPD3 MAP2K1 MAP2K3 MAP2K5 MAPK8IP1 MAPK8IP2 MATK MDH1 MEPCE MERTK MET MSN MST1R MTCH1 MUC1 MUC4 MUCL1 MYC MYO9A NAT2 NCK1 NCK2 NEFH NF2 NINL NRG1 NTRK1 NTRK2 NTRK3 NUDT16L1 ODF2L PABPC1 PAK1 PDCD11 PDGFRA PDGFRB PEBP1 PGAM1 PHF23 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 POLD2 POU6F1 PPA1 PPM1A PPM1F PRDM14 PRDX5 PSAP PSMA1 PSMC3 PSMC3IP PSMD3 PTGES3L-AARSD1 PTK2 PTK2B PTK6 PTK7 PTPN11 PTPN18 PTPN6 PTPRR PTPRT PTPRU RAB5C RAF1 RASA1 RASSF1 RBM15B RET RHBDD2 RHOBTB2 RIN1 RIN2 ROR2 RPRML RTN4 S100A11 SAFB2 SELENOK SERPINA3 SFRP4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH2D5 SH3BGRL3 SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SLC7A4 SMAD1 SMIM20 SMPD4 SNAP91 SOCS1 SOCS3 SOCS5 SOCS6 SOS1 SPP1 SRC SRPK1 STAP1 STAT3 STIP1 STK11 STK24 STMN1 STMN2 STUB1 STYK1 STYX SUPT6H SYK SYNM TCEAL2 TEC TGFA TGFB1 THRSP TLN1 TMA7 TMEM134 TMEM230 TNS1 TNS2 TNS3 TOB1 TP53 TRIP6 TRMO TSEN15 TTC9B TTYH2 TVP23B TXK TXN TYMP TYRO3 UBB USP2 UTP18 VAPA VAV1 VAV2 VAV3 YES1 YWHAZ ZAP70 ZFAND1 ZMAT2 ZMYND8 ZNF189 ZNF532
Entrez ID		4582	2064
HPRD ID		01152	01281
Ensembl ID		ENSG00000185499	ENSG00000141736
Uniprot IDs		A0A087X0L2 A0A087X2A4 A0A0A0MRB3 A0A0C4DGW3 A0A384NPK6 A5YRU5 A5YRU7 A5YRV0 A5YRV2 A6ZID6 A6ZID7 A6ZIE4 A6ZIE6 B6ECB3 P15941 Q7Z538 Q7Z551	F5H1T4 J3QLU9 P04626 X5DNK3
PDB IDs		1SM3 2ACM 2FO4 5T6P 5T78 6FZQ 6FZR 6KX1 6TGG	1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 5K33 5KWG 5MY6 5O4G 5OB4 5TQS 6ATT 6BGT 6J71 6OGE
Enriched GO Terms of Interacting Partners?
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