MMP9 and RECK

Data Source:
HPRD (in vitro)

		MMP9	RECK
Description		matrix metallopeptidase 9	reversion inducing cysteine rich protein with kazal motifs
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway
	Biological Process	Skeletal System Development Ossification Positive Regulation Of Protein Phosphorylation Proteolysis Embryo Implantation Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Positive Regulation Of Cell Migration Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Cellular Response To Cadmium Ion Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Positive Regulation Of Receptor Binding Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cation Channel Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways		Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Glutathione Marimastat Minocycline Captopril Glucosamine Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		31 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI THBS1 THBS2 TIMP3	42 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704
Entrez ID		4318	8434
HPRD ID		00387	05567
Ensembl ID		ENSG00000100985	ENSG00000122707
Uniprot IDs		P14780	A8K9D8 O95980 Q6P9E2
PDB IDs		1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM
Enriched GO Terms of Interacting Partners?
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