ASCL1 and NEUROG2

Data Source:
HPRD (two hybrid, in vitro)

		ASCL1	NEUROG2
Description		achaete-scute family bHLH transcription factor 1	neurogenin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding BHLH Transcription Factor Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Noradrenergic Neuron Development Noradrenergic Neuron Fate Commitment Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Neuroblast Fate Determination Neuroblast Proliferation Sensory Organ Development Heart Development Response To Lithium Ion Regulation Of Gene Expression Oligodendrocyte Development Spinal Cord Association Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Vestibular Nucleus Development Cerebral Cortex GABAergic Interneuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Cerebral Cortex Development Neurogenesis Neuron Differentiation Regulation Of Epithelial Cell Differentiation Response To Retinoic Acid Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Sympathetic Nervous System Development Neuron Fate Commitment Neuron Fate Specification Neuron Development Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Musculoskeletal Movement, Spinal Reflex Action Response To Folic Acid Subpallium Neuron Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Olfactory Pit Development Lung Epithelial Cell Differentiation Ventral Spinal Cord Interneuron Fate Commitment Lung Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Carotid Body Glomus Cell Differentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Response To Epidermal Growth Factor Cellular Response To Magnetism Positive Regulation Of Neural Precursor Cell Proliferation	Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity
Pathways		NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases		Congenital central hypoventilation syndrome (CCHS)
GWAS		C-reactive protein levels ( 30388399 21300955) Menopause (age at onset) ( 26414677) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Meat-related diet ( 32066663) Neuroblastoma (pediatric) ( 32599975) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: BMP2 EP300 MEF2A MEF2C MEF2D MTNR1A NEUROG2 TCF4 UBQLN1 UBQLN2 USP20	2 interacting genes: ASCL1 PFDN5
Entrez ID		429	63973
HPRD ID		00011	06976
Ensembl ID		ENSG00000139352	ENSG00000178403
Uniprot IDs		P50553	Q9H2A3
PDB IDs
Enriched GO Terms of Interacting Partners?
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