MIF and GORASP2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MIF	GORASP2
Description		macrophage migration inhibitory factor	golgi reassembly stacking protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Membrane
	Molecular Function	Dopachrome Isomerase Activity Cytokine Activity Cytokine Receptor Binding Protein Binding Chemoattractant Activity Identical Protein Binding Phenylpyruvate Tautomerase Activity	Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine Production Inflammatory Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Macrophage Chemotaxis Carboxylic Acid Metabolic Process Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Interleukin-12-mediated Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Neutrophil Degranulation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Chemotaxis Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Cycle Arrest Negative Regulation Of Cell Aging Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	Organelle Organization Golgi Organization Spermatogenesis Cell Differentiation Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Plasma Membrane Organelle Assembly
Pathways		Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Golgi Cisternae Pericentriolar Stack Reorganization
Drugs		3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS		Blood protein levels ( 30072576) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macrophage Migration Inhibitory Factor levels ( 27989323)	Cognitive performance ( 19734545)
Interacting Genes		13 interacting genes: BEX3 BNIPL CD74 COPS5 COPS6 EGFR GORASP2 NME1 NTAQ1 STRN4 TP53 UPF2 ZNF408	143 interacting genes: AAMDC ACY3 ALKBH4 APIP APP ARHGEF15 ARL6IP1 ASMTL ATP6V1G1 ATXN1L BEND5 BLZF1 BTBD3 C1orf94 C21orf91 CARHSP1 CBLB CBY1 CCDC153 CCDC90B CDA CDC23 CDK18 CDKN2D CEP76 CGGBP1 CHMP1A CNTNAP2 CRYAA CRYAA2 CRYAB DCTD DMC1 DNAJB13 DPYSL2 DUSP21 DUSP4 DYRK3 ECHDC1 EIF2B1 EMILIN3 ENOX1 ENOX2 ETHE1 FIG4 GABPB2 GNG7 GNGT1 GOLGA2 GOLGA6L2 GSTZ1 GTF2IRD1 HOXC5 HSBP1 HSPB11 JADE2 KCTD13 KCTD5 KCTD7 KCTD9 KIFC3 KRTAP5-11 LONRF1 LTBP3 MAP1LC3B MAPK1 MAPK14 MAPK8 MATN4 MID2 MIEN1 MIF MORN2 MPLKIP MSC MYOM3 NCOA5 NHSL2 NME1 NMNAT1 NQO2 NUDT5 NUP62 ODC1 PCBD1 PDE9A PNMA5 PRDX3 PRKAB2 PRPS1 PRRC2A PSMA3 PSMD6 RAB1A RAB27B RAB2A RAB39A RAD54B RBM46 REEP6 RGL2 RGS3 RPIA RPS6KA1 SCAND1 SELENBP1 SEPTIN1 SEPTIN14 SHMT1 STOX1 TAGLN TCF4 TEKT3 TGFA TLE5 TMED10 TMED2 TMED3 TP53RK TPH1 TRAF1 TRAF2 TRAF4 TRAF5 TRAPPC6A TRIM38 TRPT1 TSC22D1 TSC22D4 TSEN15 TSN TTC19 TXLNA UBE2Z UBL3 VPS37B VPS52 XPNPEP1 ZBED1 ZBTB14 ZMAT1 ZMYND19 ZNF148
Entrez ID		4282	26003
HPRD ID		01091	08303
Ensembl ID		ENSG00000240972	ENSG00000115806
Uniprot IDs		I4AY87 P14174	Q9H8Y8
PDB IDs		1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ 4PLU 4TRF 4TRU 4WR8 4WRB 4XX7 4XX8 4Z15 4Z1T 4Z1U 5B4O 5BS9 5BSC 5BSI 5BSJ 5EIZ 5HVS 5HVT 5HVV 5J7P 5J7Q 5UMJ 5UMK 5UZY 5V70 5V73 5XEJ 6B1C 6B1K 6B2C 6BG6 6BG7 6CB5 6CBF 6CBG 6CBH 6FVE 6FVH 6OY8 6OYB 6OYE 6OYG 6PEG	3RLE 4EDJ
Enriched GO Terms of Interacting Partners?
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