RAB8A and ODF2

Data Source:
BioGRID (two hybrid, pull down)

		RAB8A	ODF2
Description		RAB8A, member RAS oncogene family	outer dense fiber of sperm tails 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Centrosome Centriole Cytosol Plasma Membrane Cilium Synaptic Vesicle Postsynaptic Density Trans-Golgi Network Transport Vesicle Midbody Phagocytic Vesicle Membrane Trans-Golgi Network Membrane Neuronal Cell Body Dendritic Spine Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome Non-motile Cilium Glutamatergic Synapse	Spindle Pole Outer Dense Fiber Nucleus Centrosome Centriole Cytosol Microtubule Sperm Flagellum Ciliary Transition Fiber Centriolar Subdistal Appendage
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding	Structural Molecule Activity Protein Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Autophagy Axonogenesis Protein Secretion Regulation Of Autophagy Regulation Of Exocytosis Cellular Response To Insulin Stimulus Post-translational Protein Modification Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	G2/M Transition Of Mitotic Cell Cycle Multicellular Organism Development Spermatid Development Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Cilium Organization Ciliary Basal Body-plasma Membrane Docking
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Red cell distribution width ( 32888494)	Body mass index ( 26426971)
Interacting Genes		23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC	16 interacting genes: APP FBXO25 ING5 LRRK1 MAP3K1 MARK4 MEOX2 ODF1 RAB8A SMURF1 SNW1 SVIL TRAF5 TRIM55 TRIM63 ZDHHC17
Entrez ID		4218	4957
HPRD ID		01296	03601
Ensembl ID		ENSG00000167461	ENSG00000136811
Uniprot IDs		A0A024R7I3 P61006	A0A024R8A4 A0A024R8A5 B3KSD5 B4DUU0 B4DX03 B4DX85 Q5BJF6
PDB IDs		3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6ZSI 6ZSJ
Enriched GO Terms of Interacting Partners?
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