Wiki-Pi
About
Search
Browse
People
Updates
Search
MEF2C and CDK1
Data Source:
HPRD
(in vitro)
MEF2C
CDK1
Description
myocyte enhancer factor 2C
cyclin dependent kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Sarcoplasm
Nuclear Speck
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Postsynapse
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Endoplasmic Reticulum Membrane
Centrosome
Cytosol
Spindle Microtubule
Membrane
Midbody
Extracellular Exosome
Mitotic Spindle
Cyclin B1-CDK1 Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Minor Groove Of Adenine-thymine-rich DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Activating Transcription Factor Binding
Histone Deacetylase Binding
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Virus Receptor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin Binding
Histone Kinase Activity
Cyclin-dependent Protein Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Blood Vessel Development
Osteoblast Differentiation
Neuron Migration
B Cell Homeostasis
Heart Looping
Endochondral Ossification
Blood Vessel Remodeling
Chondrocyte Differentiation
Germinal Center Formation
Regulation Of Germinal Center Formation
Primary Heart Field Specification
Secondary Heart Field Specification
Outflow Tract Morphogenesis
Sinoatrial Valve Morphogenesis
Cardiac Ventricle Formation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Humoral Immune Response
Nervous System Development
Heart Development
Muscle Organ Development
Skeletal Muscle Tissue Development
Muscle Cell Fate Determination
Learning Or Memory
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Alkaline Phosphatase Activity
Neural Crest Cell Differentiation
Myotube Differentiation
Cell Differentiation
Neuron Differentiation
Platelet Formation
Negative Regulation Of Ossification
Melanocyte Differentiation
Positive Regulation Of Bone Mineralization
Positive Regulation Of B Cell Proliferation
Cellular Response To Drug
Cellular Response To Trichostatin A
B Cell Proliferation
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Neurotransmitter Secretion
Regulation Of Synaptic Plasticity
Positive Regulation Of Skeletal Muscle Tissue Development
Neuron Development
Cell Morphogenesis Involved In Neuron Differentiation
B Cell Receptor Signaling Pathway
Smooth Muscle Cell Differentiation
Positive Regulation Of Muscle Cell Differentiation
Regulation Of Synapse Assembly
Regulation Of Synaptic Transmission, Glutamatergic
Ventricular Cardiac Muscle Cell Differentiation
Regulation Of Synaptic Activity
Positive Regulation Of Cardiac Muscle Cell Proliferation
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Development
Renal Tubule Morphogenesis
Cellular Response To Lipopolysaccharide
Cellular Response To Calcium Ion
Cellular Response To Parathyroid Hormone Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Transforming Growth Factor Beta Stimulus
Glomerulus Morphogenesis
Nephron Tubule Epithelial Cell Differentiation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Macrophage Apoptotic Process
Regulation Of NMDA Receptor Activity
Regulation Of AMPA Receptor Activity
Positive Regulation Of Cardiac Muscle Cell Differentiation
Positive Regulation Of Behavioral Fear Response
Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Positive Regulation Of Skeletal Muscle Cell Differentiation
G2/M Transition Of Mitotic Cell Cycle
Activation Of MAPK Activity
Microtubule Cytoskeleton Organization
DNA Replication
DNA Repair
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Nuclear Envelope Disassembly
Mitotic G2 DNA Damage Checkpoint
Centrosome Cycle
Pronuclear Fusion
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Schwann Cell Differentiation
Cell Migration
Histone Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Epithelial Cell Differentiation
Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Kinetochore
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Embryonic Development
Viral Entry Into Host Cell
Rhythmic Process
Cell Division
Golgi Disassembly
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Pathways
ERK/MAPK targets
Transcriptional activation of mitochondrial biogenesis
Circadian Clock
Myogenesis
MECP2 regulates transcription factors
MAPK3 (ERK1) activation
E2F-enabled inhibition of pre-replication complex formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Golgi Cisternae Pericentriolar Stack Reorganization
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Transcriptional regulation by RUNX2
Drugs
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
Seliciclib
AT-7519
Fostamatinib
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Accelerometer-based physical activity measurement (average acceleration) (
29899525
)
Adult body size (
32376654
)
Alcohol consumption (
31358974
)
Alcohol consumption (drinks per week) (
30643258
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
24162737
)
anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) (
31835028
)
Attention deficit hyperactivity disorder (
29325848
)
Bipolar disorder lithium response (categorical) or schizophrenia (
29121268
)
Body mass index (
26426971
)
Bone mineral density (
21533022
24249740
23572186
)
Bone mineral density (hip) (
19801982
)
Bone mineral density (total hip) (
29883787
)
Bone mineral density (Ward's triangle area) (
27397699
)
Chronotype (
30696823
)
Cognitive ability (
29186694
)
Cognitive ability (MTAG) (
29186694
)
Depression (
29700475
)
Femoral neck bone mineral density (
29499414
32239398
22504420
)
Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass (
32239398
)
General cognitive ability (
29844566
)
Glomerular filtration rate in chronic kidney disease (
26420894
)
Height (
20881960
25282103
25429064
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Household income (MTAG) (
31844048
)
Intelligence (
28530673
)
Intelligence (MTAG) (
29326435
)
Lamb consumption (
32066663
)
Lymphocyte percentage of white cells (
32888494
)
Major depressive disorder (
27479909
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean platelet volume (
22139419
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Morning person (
30696823
)
Multiple sclerosis (
31604244
)
Number of sexual partners (
30643258
)
Photic sneeze reflex (
27182965
)
Platelet count (
22139419
32888494
27863252
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Red blood cell count (
32888494
27863252
)
Refractive error (
32231278
)
Regular attendance at a religious group (
29970889
)
Retinal arteriolar caliber (
23776548
)
Retinal vascular caliber (
21060863
)
Rosacea symptom severity (
29771307
)
Schizophrenia (
25056061
30285260
)
Smoking status (ever vs never smokers) (
30643258
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Tonometry (
17903302
)
Vascular endothelial growth factor levels (
26910538
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for body mass index (
28448500
)
Cocaine dependence (
23958962
)
Voxel-wise structural brain imaging measurements in Alzheimer’s disease (
31095298
)
Interacting Genes
30 interacting genes:
ASCL1
CCNB1
CDK1
COPS5
CSNK2A1
EP300
EPAS1
GATA4
HDAC4
HDAC5
HDAC7
HDAC9
MAPK14
MAPK7
MEF2D
MYOD1
MYOG
NCOA2
NOTCH1
PLA2G12A
SMAD2
SOX18
SP1
SPTBN1
TEAD1
TWIST2
UBE2I
VGLL2
VGLL4
YWHAZ
186 interacting genes:
ABL1
AMPH
APLP2
AR
ARID4A
BARD1
BCL2
BIRC5
BIRC6
BRCA1
BRCA2
BTRC
BUB1
CALD1
CCNA1
CCNA2
CCNB1
CCNB1IP1
CCNB2
CCNE1
CCP110
CD8A
CDC20
CDC25A
CDC25B
CDC25C
CDC6
CDCA2
CDCA5
CDK7
CDKN1A
CDKN1B
CDKN3
CDT1
CEP55
CEP63
CHAF1B
CIITA
CKS2
CNOT7
CREM
CSN2
CSNK2A1
CSNK2B
CUX1
CXCR1
DAB2
DCTN6
DNM2
DTL
DUT
E2F1
ECT2
EEF1D
EEF2K
EGFR
EP300
EPN1
ERCC2
FANCA
FANCC
FANCG
FBXO5
FEN1
FOXM1
FYN
GADD45A
GADD45B
GADD45G
GATA2
GBF1
GFAP
GOLGA2
GORASP1
H1-0
H1-1
H1-3
H1-5
H2AC4
H2BC3
H4C1
HMGA1
HMGA2
HMGB1
HSPA2
HTRA2
IL16
IL3RA
ITGB3
ITPR1
JAK3
KAT5
KHDRBS1
KIF11
KIF20B
KIF26B
KMT2E
KRT18
LATS1
LMNA
LMNB1
LYN
LZTS1
MAP4
MAPT
MARCKS
MBP
MCM4
MDM4
MEF2C
MKI67
MLKL
MNDA
MYC
MYT1
NCAPD2
NCAPG
NCAPH
NCL
NDE1
NES
NPM1
NSFL1C
NUP210
PAK6
PBK
PCNA
PIN1
PITPNM1
PKMYT1
PLEC
PML
POLA1
PPP2R1A
PPP2R1B
PPP2R2B
PRC1
PTCH1
PTMA
PTPN1
PTPN2
PTPN6
PTTG1
RAB4A
RAB5B
RACGAP1
RAP1GAP
RB1
RCC1
RELB
REPS2
RGCC
RPA2
RPS6KB1
RRM2
RUNX1
RUNX2
SFN
SP1
SPAG5
SQSTM1
SRC
SSBP1
STK3
STMN1
STMN2
TFDP1
TGFBR2
TK1
TLE1
TNNC1
TOP2A
TP53
TP53BP1
TP73
TSC1
TSPYL2
UBA1
UBE2A
UBE3A
UHRF2
USP16
VIM
WEE1
XIAP
ZBTB16
Entrez ID
4208
983
HPRD ID
02809
00302
Ensembl ID
ENSG00000081189
ENSG00000170312
Uniprot IDs
A0A024RAL6
A0A024RAL7
A0A0D9SGI5
D8L7E9
Q06413
A0A024QZJ8
B7Z3D6
I6L9I5
P06493
PDB IDs
1LC9
4Y72
4YC3
4YC6
5HQ0
5LQF
6GU2
6GU3
6GU4
6GU6
6GU7
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?