MIRLET7E and IGF2BP2

Data Source:
BioGRID (unspecified method)

		MIRLET7E	IGF2BP2
Description		microRNA let-7e	insulin like growth factor 2 mRNA binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Nucleus Cytoplasm Cytosol Cytoskeleton
	Molecular Function	MRNA Binding Involved In Posttranscriptional Gene Silencing	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Translation Regulator Activity MRNA 5'-UTR Binding
	Biological Process	Negative Regulation Of Interleukin-6 Production Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Signaling Receptor Activity	Regulation Of Cytokine Production Nervous System Development Anatomical Structure Morphogenesis Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of MRNA Stability MRNA Transport Regulation Of RNA Metabolic Process
Pathways			Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Drugs
Diseases			Type II diabetes mellitus
GWAS			Acute insulin response ( 28490609) Blood sugar levels ( 29403010) Body mass index ( 29381148 28892062) Coronary artery disease ( 29212778) Diabetes (gestational) ( 22233651) Fasting blood glucose (BMI interaction) ( 22581228) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 31562340) Hemoglobin A1c levels ( 29403010) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Monocyte count ( 32888494) Peak expiratory flow ( 30804560) Peak insulin response ( 28490609) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Thyroid stimulating hormone levels ( 30367059 32769997) Triglyceride levels ( 32203549) Type 2 diabetes ( 21573907 27189021 22885922 18372903 24509480 30054458 18711366 26961502 29358691 30297969 29632382 23945395 31118516 25760438 23300278 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		105 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PLRG1 PRMT1 PTBP1 PUF60 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RBM47 RBM5 RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR ZNF346	72 interacting genes: HNRNPD MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I
Entrez ID		406887	10644
HPRD ID			10507
Ensembl ID		ENSG00000198972	ENSG00000073792
Uniprot IDs			B3FTN5 B4DKT5 F8W930 Q9Y6M1
PDB IDs			2CQH 6ROL
Enriched GO Terms of Interacting Partners?
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