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LRP1 and CCN2
Data Source:
HPRD
(in vivo)
LRP1
CCN2
Description
LDL receptor related protein 1
cellular communication network factor 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Lysosomal Membrane
Early Endosome
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Basolateral Plasma Membrane
Clathrin-coated Vesicle
Dendrite
Endocytic Vesicle Membrane
Insulin-responsive Compartment
Neuronal Cell Body
Receptor Complex
Axonal Growth Cone
Apical Part Of Cell
Plasma Membrane Protein Complex
Postsynaptic Golgi Apparatus
Extracellular Region
Extracellular Space
Cis-Golgi Network
Cytosol
Plasma Membrane
Cell Cortex
Extracellular Matrix
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Molecular Function
Amyloid-beta Binding
Protease Binding
RNA Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Calcium Ion Binding
Protein Binding
Coreceptor Activity
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Clathrin Heavy Chain Binding
Apolipoprotein Binding
Signaling Receptor Activity
Cargo Receptor Activity
Heparan Sulfate Proteoglycan Binding
Protein-containing Complex Binding
Lipoprotein Particle Receptor Binding
Fibronectin Binding
Integrin Binding
Protein Binding
Insulin-like Growth Factor Binding
Protein C-terminus Binding
Growth Factor Activity
Heparin Binding
Biological Process
Retinoid Metabolic Process
Astrocyte Activation Involved In Immune Response
Lipid Metabolic Process
Receptor-mediated Endocytosis
Phagocytosis
Lysosomal Transport
Positive Regulation Of Cytosolic Calcium Ion Concentration
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Aging
Cell Population Proliferation
Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Cell Death
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Smooth Muscle Cell Migration
Cerebral Cortex Development
Negative Regulation Of Wnt Signaling Pathway
Receptor Internalization
Positive Regulation Of Protein Binding
Positive Regulation Of Lipid Transport
Regulation Of Cholesterol Transport
Regulation Of Phospholipase A2 Activity
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Aorta Morphogenesis
Lipoprotein Metabolic Process
Lipoprotein Transport
Apoptotic Cell Clearance
Negative Regulation Of Neuron Apoptotic Process
Cellular Lipid Catabolic Process
Transcytosis
Positive Regulation Of Endocytosis
Positive Regulation Of Axon Extension Involved In Regeneration
Positive Regulation Of Collateral Sprouting Of Injured Axon
Positive Regulation Of Phagocytosis
Negative Regulation Of Cytosolic Calcium Ion Concentration
Negative Regulation Of Focal Adhesion Assembly
Chemoattraction Of Axon
Positive Regulation Of ERK1 And ERK2 Cascade
Amyloid-beta Clearance
Amyloid-beta Clearance By Transcytosis
Amyloid-beta Clearance By Cellular Catabolic Process
Transport Across Blood-brain Barrier
Positive Regulation Of Schwann Cell Migration
Positive Regulation Of Amyloid-beta Clearance
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cholesterol Import
Positive Regulation Of Transcytosis
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Metallopeptidase Activity
Positive Regulation Of Lysosomal Protein Catabolic Process
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Cartilage Condensation
Ossification
Angiogenesis
Tissue Homeostasis
Positive Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase II Promoter
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Aging
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Epidermis Development
Response To Wounding
Response To Glucose
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Death
Cell Migration
Cell Differentiation
Lung Development
Regulation Of Chondrocyte Differentiation
Response To Estradiol
Positive Regulation Of Collagen Biosynthetic Process
Response To Anoxia
Intracellular Signal Transduction
Chondrocyte Proliferation
Response To Amino Acid
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of Cell Differentiation
Positive Regulation Of JNK Cascade
Positive Regulation Of Cell Activation
Response To Mineralocorticoid
Positive Regulation Of Stress Fiber Assembly
Cytosolic Calcium Ion Transport
Positive Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Cell Death
Extracellular Matrix Constituent Secretion
Positive Regulation Of G0 To G1 Transition
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Fatty Acid
DNA Biosynthetic Process
Reactive Oxygen Species Metabolic Process
Pathways
Scavenging of heme from plasma
Retinoid metabolism and transport
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
Drugs
Antihemophilic factor, human recombinant
Tenecteplase
Coagulation Factor IX (Recombinant)
Lanoteplase
Coagulation Factor IX Human
Lonoctocog alfa
Moroctocog alfa
Diseases
GWAS
Abdominal aortic aneurysm (
27899403
22055160
)
Adult asthma (
30787307
)
Asthma (
31959851
27182965
31619474
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Body mass index (
28552196
)
Cervical artery dissection (
25420145
)
Coronary artery disease (
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
28334899
)
Headache (
29397368
)
Height (
31562340
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (anilides) (
31015401
)
Medication use (antimigraine preparations) (
31015401
)
Migraine (
22683712
27182965
23793025
21666692
27322543
)
Migraine - clinic-based (
23793025
)
Migraine without aura (
23793025
27322543
)
Moyamoya disease (
29273593
)
Peak expiratory flow (
30804560
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Spontaneous coronary artery dissection (
32887874
32374345
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
25961943
20686565
)
Interacting Genes
70 interacting genes:
A2M
ANAPC10
ANKS1B
APBA2
APBB1
APOE
APP
BACE1
BDNF
C3
C4BPA
CACNA1A
CALR
CANX
CAV1
CC2D1A
CCN2
CD82
CTSG
DAB1
DAB2
DLG4
EGFR
ELANE
F8
F9
FURIN
GIPC1
GTPBP1
GULP1
HNRNPDL
HSP90B1
ITGB1BP1
KAT5
LIPC
LPL
LRPAP1
LTF
MAPK8IP1
MAPK8IP2
MAPRE1
MDK
MMP13
MMP14
MMP15
MMP16
MMP17
MTDH
NGF
NOS1AP
NTF3
NTF4
PDGFB
PID1
PLAT
PLAUR
PRKACA
PTPN11
RIC8B
SCN3A
SERPINA1
SERPINE1
SHC1
SKIL
SNRNP70
SNX17
SRC
SYNJ2BP
THBS1
WNT3A
13 interacting genes:
ACTB
AP3D1
CCN3
ERBB4
FBLN1
HSPG2
LIMS1
LRP1
MTDH
TGFB1
TGFB2
TGFB3
VEGFA
Entrez ID
4035
1490
HPRD ID
00138
00412
Ensembl ID
ENSG00000123384
ENSG00000118523
Uniprot IDs
Q07954
Q59FG2
P29279
Q5M8T4
PDB IDs
1CR8
1D2L
1J8E
2FYJ
2FYL
2KNX
2KNY
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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