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LCK and SHC1
Data Source:
HPRD
(in vivo)
LCK
SHC1
Description
LCK proto-oncogene, Src family tyrosine kinase
SHC adaptor protein 1
Image
GO Annotations
Cellular Component
Pericentriolar Material
Immunological Synapse
Cytosol
Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Membrane Raft
Extracellular Exosome
Mitochondrial Matrix
Cytosol
Plasma Membrane
Shc-EGFR Complex
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Serine/threonine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
ATPase Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phospholipid Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ephrin Receptor Binding
Epidermal Growth Factor Binding
Biological Process
Protein Phosphorylation
Protein Dephosphorylation
Cellular Zinc Ion Homeostasis
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Cell Differentiation
Platelet Activation
T Cell Differentiation
T Cell Costimulation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Response To Drug
Innate Immune Response
Regulation Of Defense Response To Virus By Virus
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Leukocyte Migration
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Lymphocyte Activation
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
MAPK Cascade
Activation Of MAPK Activity
Angiogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Ras Protein Signal Transduction
Axon Guidance
Heart Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Actin Cytoskeleton Reorganization
Interleukin-15-mediated Signaling Pathway
IRE1-mediated Unfolded Protein Response
Fc-epsilon Receptor Signaling Pathway
Interleukin-2-mediated Signaling Pathway
ERBB2 Signaling Pathway
Regulation Of Growth
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Ras Protein Signal Transduction
Leukocyte Migration
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cell-cell Adhesion
Pathways
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-2 signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
FLT3 signaling through SRC family kinases
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Dasatinib
AP-22408
Staurosporine
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
{4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid
Phosphoaminophosphonic Acid-Adenylate Ester
3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE
5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
Ponatinib
Nintedanib
Fostamatinib
Zanubrutinib
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS
Multiple sclerosis (
31604244
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Eosinophil counts (
29403010
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
27569725
)
Prostate cancer (
23535732
)
Interacting Genes
143 interacting genes:
ACP1
ADAM15
AJUBA
AR
ARHGAP17
ASB9
AXL
BCAR1
BRCA1
C1QTNF2
CBL
CCR5
CD2
CD247
CD28
CD38
CD3E
CD4
CD44
CD48
CD5
CD55
CD79A
CD79B
CD8A
CDC25C
CDC42
CDC45
CDKAL1
CSF2RB
CSF3R
CSK
CSNK2B
CTDSP1
CTLA4
CTNND1
CTNND2
DAPP1
DEF6
DLG1
DOK1
DOK2
DOK3
EGFR
ERBB2
ERBB3
ERBB4
ESR1
ESR2
EZR
FAM166B
FAM174A
FAS
FASLG
FCGR3A
FYN
G3BP1
GAB1
GAB2
GATA3
GRAP
HSP90AA1
IFNAR1
IKBKG
IL2RB
ITK
JAK3
KHDRBS1
KIR2DL3
KIT
LAT
LAX1
LCP2
LIME1
LZTS2
MAPK1
MAPK3
MAPT
MED28
MET
MS4A1
MUC1
NEDD9
NFKBIA
NFKBID
NOTCH1
NR3C1
PAG1
PAK2
PECAM1
PI4KA
PIK3CA
PIK3R1
PLCG1
PLCG2
PLD2
PRKACA
PRKCA
PRKCD
PRKCQ
PTK2
PTK2B
PTPN11
PTPN22
PTPN6
PTPRC
PTPRF
PTPRH
PXN
RAF1
RASA1
RIN3
RORB
SH2B3
SH2D1A
SH2D2A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SMAD2
SMAD3
SMURF1
SOS1
SQSTM1
STAT1
STAT3
STAT5A
SYK
THY1
TRAT1
TRIM35
TRPV4
TUB
UBAP2
UBE3A
UHRF2
UNC119
VAV1
WAS
WASL
ZAP70
143 interacting genes:
ALK
AP2A1
AP2A2
APP
AR
AXL
BCL3
BCR
BUB1
C11orf58
CALCOCO2
CALD1
CBL
CBLB
CBLC
CD22
CD247
CD3E
CD81
CDH5
CEACAM1
CRK
CRKL
CSF1R
CSF2RB
CSF3R
CSK
DAG1
DDR1
DDR2
DOK1
DUSP23
EGFR
EPHA2
EPOR
EPS8
ERBB2
ERBB3
ERBB4
ESR1
FAM118B
FBXW7
FCGR2A
FCGR3A
FGFR1
FGFR2
FLT1
FLT4
FYN
GAB1
GAB2
GEMIN7
GH1
GHR
GRAP
GRAP2
GRB2
GRB7
HMOX2
IGF1R
IL2
IL2RB
IL2RG
IL4R
IL6ST
ILK
INPP5D
INPPL1
INSR
IRS1
IRS2
ITGB3
ITGB4
JAK2
KDR
KIT
KRT18
LCK
LCP2
LRP1
LTK
LYN
MAP4K1
MAPK1
MAPK14
MAPK6
MAPK8
MAPKAPK2
MET
MME
MPL
MRPL44
MST1R
NGFR
NPM1
NTRK1
NTRK2
NTRK3
NUDT21
OSGEP
PAG1
PAK1
PDGFRB
PIK3C2B
PIK3R1
PIK3R2
PLCG1
PLCG2
PLPP3
PLSCR1
PPP2R5A
PRKCA
PRKCD
PRKRA
PTK2
PTK2B
PTPN11
PTPN12
PTPN2
PTPN6
RAPGEF1
RASA1
RB1
RET
SH2B2
SHCBP1
SMAD4
SOS1
SOS2
SP1
SRC
STAT5A
STAT5B
SUV39H2
SYK
TEC
TEK
TPR
TRIM15
UBASH3B
VAV1
VAV3
ZAP70
Entrez ID
3932
6464
HPRD ID
01080
02780
Ensembl ID
ENSG00000182866
ENSG00000160691
Uniprot IDs
A0A0S2Z3Y4
A0A0S2Z3Y8
P06239
Q573B4
P29353
PDB IDs
1BHF
1BHH
1CWD
1CWE
1FBZ
1H92
1IJR
1KIK
1LCJ
1LCK
1LKK
1LKL
1Q68
1Q69
1QPC
1QPD
1QPE
1QPJ
1X27
2IIM
2OF2
2OF4
2OFU
2OFV
2OG8
2PL0
2ZM1
2ZM4
2ZYB
3AC1
3AC2
3AC3
3AC4
3AC5
3AC8
3ACJ
3ACK
3AD4
3AD5
3AD6
3B2W
3BRH
3BYM
3BYO
3BYS
3BYU
3KMM
3KXZ
3LCK
3MPM
4C3F
4D8K
5MTM
5MTN
6H6A
6PDJ
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
1WCP
2L1C
4JMH
4XWX
5CZI
6DM4
Enriched GO Terms of Interacting Partners
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