LAMA4 and TUBB2A

Data Source:
BioGRID (two hybrid)

		LAMA4	TUBB2A
Description		laminin subunit alpha 4	tubulin beta 2A class IIa
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Cytoplasm Microtubule Extracellular Exosome Extracellular Vesicle
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Cell Adhesion Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Regulation Of Embryonic Development Negative Regulation Of Cold-induced Thermogenesis	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans MET activates PTK2 signaling	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs			CYT997 Phenethyl Isothiocyanate
Diseases
GWAS		Bipolar disorder ( 31043756) Metabolite levels ( 23823483)	Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494 27863252)
Interacting Genes		17 interacting genes: APC ATF7IP BRD7 COPS6 EEF1A1 FHL1 GAPDH LRIF1 MED31 PTN RTN4 RTP2 TP53 TUBB2A UBR1 UNC119 ZHX1	27 interacting genes: ACD ARL15 ARNT CHGB DISC1 DUX4 HDAC6 HGS HMMR LAMA4 LINC01554 PAFAH1B3 POT1 PSMD11 PTPRS RABAC1 RIC8A RPA2 RPLP1 SAT1 SDC3 SERPINB9 TERF1 TK1 TNIK TPT1 UPF2
Entrez ID		3910	7280
HPRD ID		02532
Ensembl ID		ENSG00000112769	ENSG00000137267
Uniprot IDs		A0A0A0MQS9 A0A0A0MTC7 Q16363 Q5D044	Q13885
PDB IDs
Enriched GO Terms of Interacting Partners?
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