LDLRAD1 and SLC1A1

Data Source:
BioGRID (two hybrid)

		LDLRAD1	SLC1A1
Description		low density lipoprotein receptor class A domain containing 1	solute carrier family 1 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Axon Dendrite Early Endosome Membrane Late Endosome Membrane Asymmetric Synapse Neuronal Cell Body Synaptic Cleft Dendritic Spine Dendritic Shaft Perikaryon Axon Terminus Recycling Endosome Membrane Extracellular Exosome Cell Periphery Glial Cell Projection Apical Dendrite Presynapse Perisynaptic Space Distal Dendrite Proximal Dendrite
	Molecular Function	Protein Binding	L-glutamate Transmembrane Transporter Activity High-affinity Glutamate Transmembrane Transporter Activity Protein Binding Chloride Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Cysteine Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding D-aspartate Transmembrane Transporter Activity
	Biological Process		Behavioral Fear Response Regulation Of Protein Phosphorylation Glutathione Metabolic Process Ion Transport Cellular Zinc Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Chemical Synaptic Transmission Learning Or Memory Positive Regulation Of Heart Rate Retina Layer Formation Glutamate Secretion L-glutamate Transmembrane Transport Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Response To Decreased Oxygen Levels Neuron Death In Response To Oxidative Stress Cysteine Transport Blood Vessel Morphogenesis Response To Axon Injury L-glutamate Import Righting Reflex Heart Contraction Long-term Synaptic Potentiation Transepithelial Transport D-aspartate Transport L-aspartate Transmembrane Transport D-aspartate Import Across Plasma Membrane Cellular Response To Ammonium Ion Response To Anesthetic Regulation Of Protein Targeting To Membrane Glutamate Homeostasis Motor Neuron Apoptotic Process L-glutamate Import Across Plasma Membrane Neurotransmitter Receptor Transport To Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport Cysteine Transmembrane Transport
Pathways			Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)
Drugs			Aspartic acid Glutamic acid
Diseases			Dicarboxylic aminoaciduria
GWAS		Parkinson disease and lewy body pathology ( 25663231)	Coronary artery calcification ( 23870195) Metabolite levels ( 23823483) Pancreatic cancer ( 22158540) Response to antipsychotic treatment in schizophrenia ( 29503163) Response to risperidone in schizophrenia ( 29503163) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		34 interacting genes: ADGRG7 ANKRD46 AQP1 BNIP2 BNIP3 BNIP3L CMTM7 CTXN3 CXCL9 EBP EMP3 GIMAP5 GPR25 IGFBP5 LAPTM5 MAL MALL MARCHF2 NINJ2 OLFM4 PLN PLPP6 PTTG1IP SEC22A SLC1A1 SLC41A2 TMEM147 TMEM190 TMEM218 TMEM79 UNC93B1 VAMP4 VTI1B ZFPL1	16 interacting genes: APP ARL6IP5 C1GALT1 ERGIC3 EWSR1 FAM209A FCER1G FXYD3 LDLRAD1 LMNA PAGE1 PRKCA RNF5 SLC35A1 SYNPR TMEM179B
Entrez ID		388633	6505
HPRD ID		17372	00597
Ensembl ID		ENSG00000203985	ENSG00000106688
Uniprot IDs		Q5T700	P43005
PDB IDs			6S3Q
Enriched GO Terms of Interacting Partners?
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