ARG1 and FLOT1

Data Source:
HPRD (in vitro)

		ARG1	FLOT1
Description		arginase 1	flotillin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol Azurophil Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body	Uropod Lysosomal Membrane Endosome Early Endosome Microtubule Organizing Center Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion COP9 Signalosome External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Cortical Actin Cytoskeleton Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Melanosome Cell-cell Contact Zone Membrane Raft Presynaptic Active Zone Extracellular Exosome Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Arginase Activity Protein Binding Manganese Ion Binding Identical Protein Binding	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Arginine Catabolic Process Aging Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Arginine Catabolic Process To Ornithine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Negative Regulation Of T Cell Proliferation Response To Drug Defense Response To Protozoan Response To Amino Acid Neutrophil Degranulation Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Neutrophil Mediated Killing Of Fungus Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of T-helper 2 Cell Cytokine Production	Membrane Raft Assembly Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Axonogenesis Extracellular Matrix Disassembly Positive Regulation Of Protein Binding Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Interferon-beta Production DsRNA Transport Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Rho Protein Signal Transduction Plasma Membrane Raft Assembly Positive Regulation Of Endocytosis Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neurotransmitter Uptake Positive Regulation Of Cell Adhesion Molecule Production Protein Kinase C Signaling Cellular Response To Exogenous DsRNA Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Cell Junction Assembly Protein Localization To Membrane Raft Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Neutrophil degranulation Urea cycle	RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules
Drugs		Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese
Diseases		Hyperargininemia
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Obesity ( 21552555) Type 2 diabetes ( 30054458)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) General cognitive ability ( 29844566) Handedness (non-right-handed vs right-handed) ( 31504236) Schizophrenia ( 30285260) Sleep duration ( 25469926) Ulcerative colitis ( 20848476)
Interacting Genes		6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5	23 interacting genes: APP ARG1 AURKB BANP CAPN10 CBL CCDC102B COX5B FAM90A1 FLOT2 FYN GOLM1 HGS INCENP NGB NME7 PSMD4 SHBG SORBS1 SORBS2 SORBS3 SRPK1 UBC
Entrez ID		383	10211
HPRD ID		01947	06105
Ensembl ID		ENSG00000118520	ENSG00000137312
Uniprot IDs		P05089	O75955 Q5ST80
PDB IDs		1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F
Enriched GO Terms of Interacting Partners?
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