KEL and EDN3

Data Source:
HPRD (in vivo)

		KEL	EDN3
Description		Kell metallo-endopeptidase (Kell blood group)	endothelin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding
	Biological Process	Cellular Calcium Ion Homeostasis Regulation Of Cell Size Cellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Negative Regulation Of Potassium Ion Transmembrane Transport	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		Peptide ligand-binding receptors	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Phosphoramidon
Diseases			Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS) Waardenburg syndrome (WS)
GWAS		Alcoholic chronic pancreatitis ( 28754779) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252)	Blood pressure ( 21909110) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hypertension ( 19430479 21909115) Metabolite levels ( 23823483) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		12 interacting genes: ADIPOQ C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EWSR1 PM20D2 TUBA1A UBC XK	5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL
Entrez ID		3792	1908
HPRD ID		00194	00570
Ensembl ID		ENSG00000197993	ENSG00000124205
Uniprot IDs		A0A077QP03 P23276	P14138 Q4FAT2
PDB IDs			6IGK
Enriched GO Terms of Interacting Partners?
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