AREG and DNAAF10

Data Source:
BioGRID (unspecified method)

		AREG	DNAAF10
Description		amphiregulin	dynein axonemal assembly factor 10
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Cytokine Activity Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Ubiquitin Binding
	Biological Process	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity COPII Vesicle Coating Positive Regulation Of Protein Kinase B Signaling Membrane Organization	Apoptotic Process
Pathways		PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation COPII-mediated vesicle transport EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade Cargo concentration in the ER PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Breast size ( 22747683 27182965) Mammographic density (dense area) ( 25342443) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)
Interacting Genes		10 interacting genes: APP CCND3 CYSRT1 DNAAF10 EGFR KRTAP10-3 KRTAP10-8 MMP9 UBQLN4 WT1	1 interacting genes: AREG
Entrez ID		374	116143
HPRD ID		00093	14012
Ensembl ID		ENSG00000109321	ENSG00000243667
Uniprot IDs		P15514	A0A140VK67 Q96MX6
PDB IDs		2RNL	3I2N
Enriched GO Terms of Interacting Partners?
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