ITPKA and ITSN2

Data Source:
BioGRID (two hybrid)

		ITPKA	ITSN2
Description		inositol-trisphosphate 3-kinase A	intersectin 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Dendritic Spine	Cytoplasm Centrosome Plasma Membrane Clathrin-coated Pit Presynaptic Membrane Extracellular Exosome Intracellular Vesicle Presynapse
	Molecular Function	Inositol Hexakisphosphate Kinase Activity Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Small GTPase Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Inositol Metabolic Process Protein Phosphorylation Signal Transduction Actin Cytoskeleton Organization Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Regulation Of Synaptic Plasticity Positive Regulation Of Dendritic Spine Morphogenesis Dendritic Spine Maintenance	Endocytosis Viral Process Endosomal Transport Cell Differentiation Regulation Of Catalytic Activity Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension
Pathways		Synthesis of IP3 and IP4 in the cytosol	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Inositol 1,3,4,5-Tetrakisphosphate 1D-myo-inositol 1,4,5-trisphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 31361310 30929738 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 23128233)	Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067)
Interacting Genes		8 interacting genes: ACTA1 CALM1 CAMK2A CAMK2B ERBB2 ITSN2 PRKACA PRKCA	75 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		3706	50618
HPRD ID		00941	09193
Ensembl ID		ENSG00000137825	ENSG00000198399
Uniprot IDs		P23677	A6H8W8 Q9NZM3
PDB IDs		1W2C 1W2D 1W2F 4UPU	1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?
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