ITPK1 and COPS8

Data Source:
HPRD (in vitro)

		ITPK1	COPS8
Description		inositol-tetrakisphosphate 1-kinase	COP9 signalosome subunit 8
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GO Annotations	Cellular Component	Cytoplasm Cytosol Apical Plasma Membrane	Nucleus Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Inositol Tetrakisphosphate 6-kinase Activity Catalytic Activity ATP Binding Hydrolase Activity Isomerase Activity Inositol Tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity	Protein Binding
	Biological Process	Signal Transduction Blood Coagulation Neural Tube Development Inositol Trisphosphate Metabolic Process Inositol Phosphate Metabolic Process Inositol Phosphorylation Necroptotic Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Post-translational Protein Modification
Pathways		Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronic obstructive pulmonary disease ( 30804561) Endometriosis ( 23472165) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Migraine ( 27182965 27322543) Platelet count ( 22139419 32888494) Plateletcrit ( 32888494 27863252) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)	Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)
Interacting Genes		6 interacting genes: COPS8 GPS1 JUN NFKBIA TP53 TRAF2	17 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA SUOX TP53 USHBP1
Entrez ID		3705	10920
HPRD ID		03501	16737
Ensembl ID		ENSG00000100605	ENSG00000198612
Uniprot IDs		A0A024R6H3 Q13572	A0A024R4D1 Q99627
PDB IDs		2ODT 2Q7D 2QB5	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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