IREB2 and USP53

Data Source:
BioGRID (two hybrid)

		IREB2	USP53
Description		iron responsive element binding protein 2	ubiquitin specific peptidase 53
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cellular_component Cell-cell Junction Bicellular Tight Junction
	Molecular Function	RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Citrate Metabolic Process Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Post-embryonic Development Negative Regulation Of Translation Osteoclast Differentiation Erythrocyte Homeostasis Intestinal Absorption Iron Ion Homeostasis	Action Potential Sensory Perception Of Sound Biological_process Response To Auditory Stimulus Protein Deubiquitination Protein Phosphopantetheinylation Neuron Apoptotic Process
Pathways		Iron uptake and transport
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 25241909 22080838 20173748) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Diffusing capacity of carbon monoxide ( 30694715) Emotional recognition ( 31596458) Emphysema distribution in smoking ( 27669027) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary artery enlargement in chronic obstructive pulmonary disease ( 25101718) Schizophrenia ( 25056061 29483656)	Body mass index ( 29273807) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: APP FBXL5 RBCK1 TERT USP53 YBX1	9 interacting genes: CRK CRKL DAB1 GRB2 IREB2 NECTIN2 SAMD4B TRAF2 UBC
Entrez ID		3658	54532
HPRD ID		08858	11669
Ensembl ID		ENSG00000136381	ENSG00000145390
Uniprot IDs		D3DW85 P48200	Q70EK8 Q9H9I0
PDB IDs		6VCD
Enriched GO Terms of Interacting Partners?
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