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INS and KRTAP1-3
Data Source:
BioGRID
(two hybrid)
INS
KRTAP1-3
Description
insulin
keratin associated protein 1-3
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Transport Vesicle
Endosome Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Secretory Granule Lumen
Cytosol
Keratin Filament
Molecular Function
Protease Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Hormone Activity
Protein Binding
Identical Protein Binding
Structural Constituent Of Skin Epidermis
Biological Process
Positive Regulation Of Cytokine Production
Negative Regulation Of Acute Inflammatory Response
Glucose Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Cellular Amino Acid Metabolic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Acute-phase Response
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Nitric Oxide Mediated Signal Transduction
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Transmembrane Transporter Activity
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Activation Of Protein Kinase B Activity
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Localization
Negative Regulation Of NAD(P)H Oxidase Activity
Wound Healing
Negative Regulation Of Protein Catabolic Process
Glucose Homeostasis
Positive Regulation Of MAPK Cascade
Cellular Protein Metabolic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Glycogen Catabolic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Proteolysis
Negative Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Insulin Receptor Signaling Pathway
Alpha-beta T Cell Activation
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Synaptic Plasticity
Regulation Of Protein Secretion
Negative Regulation Of Protein Secretion
Cognition
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Fatty Acid Homeostasis
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Positive Regulation Of Respiratory Burst
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Brown Fat Cell Differentiation
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Dendritic Spine Maintenance
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Neuron Projection Maintenance
Negative Regulation Of Feeding Behavior
Biological_process
Keratinization
Pathways
Regulation of gene expression in beta cells
Insulin processing
Insulin processing
Synthesis, secretion, and deacylation of Ghrelin
Regulation of insulin secretion
COPI-mediated anterograde transport
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Amyloid fiber formation
Keratinization
Drugs
Zinc
M-Cresol
Myristic acid
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Maturity onset diabetes of the young (MODY)
Type I diabetes mellitus
Permanent neonatal diabetes mellitus (PNDM)
GWAS
Birth weight (
27680694
)
Celiac disease (
23936387
)
Latent autoimmune diabetes vs. type 2 diabetes (
30254083
)
Pediatric autoimmune diseases (
26301688
)
Prostate cancer (
19767753
)
Prostate cancer (SNP x SNP interaction) (
22219177
)
Type 1 diabetes (
30659077
21829393
17632545
25751624
32005708
19430480
17554260
31152121
)
Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) (
29310926
)
Type 1 diabetes in high risk HLA genotype individuals (time to event) (
29310926
)
Type 2 diabetes (
31324766
30297969
31049640
32499647
30718926
)
Interacting Genes
31 interacting genes:
ADAMTSL4
APP
CCN3
CPE
CRYAB
CTSB
CTSD
CTSE
CYSRT1
GCK
HLA-DQA2
HLA-DQB1
HSPA1A
HSPB1
IDE
IGF1R
IGFBP7
INSR
KMT2A
KRTAP1-1
KRTAP1-3
LRP2
MAPK6
NBPF19
NOTCH2NLA
PTEN
RB1
RGS20
SYTL4
TCF4
TXNDC17
176 interacting genes:
ADAM12
AGA
ALDH3B1
ALPP
ATG9A
BCAM
BHLHE40
BMP7
BTC
C19orf25
C2orf68
CATSPER1
CELF5
CHIC2
CHRD
CHRNG
CLDN2
CMTM8
CNNM3
COA5
COL8A1
CRCT1
CREB5
CRH
CRY2
CTNNBIP1
CXCL16
CYHR1
CYP21A2
CYSRT1
DHRS1
DLGAP3
DMRT3
DOCK2
ECE1
FBXW5
GLP1R
GLRX3
GNE
GRAP2
GSTP1
HCK
HHEX
HHIPL1
HOXA1
HOXB9
HOXC8
HPCAL1
HSD3B7
IGSF8
IL10
IL16
INPP5D
INS
ITGB4
ITGB5
JOSD1
KLHL38
KPRP
KRTAP10-1
KRTAP10-11
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP5-11
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-8
LCE1A
LCE1B
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LONRF1
LRFN4
MAPKBP1
MOS
MTNR1A
MXD3
MXI1
MYPOP
NAXD
NECTIN2
NECTIN3
NID2
NMU
NPBWR2
NPDC1
NR1D2
NUFIP2
OLFM2
OTX1
P3H3
PDE9A
PDIA5
PHETA1
PHLDA1
PIGS
PLEKHN1
PRKAA2
PRKAB2
PRPF31
PSMA1
PTK7
PTPMT1
PVR
R3HDM2
RAMAC
RANBP3
RASD1
RPN1
RPS19BP1
SAPCD2
SDC3
SDCBP
SELENOM
SHFL
SLC13A5
SLC22A23
SLC23A1
SLC39A7
SLC43A2
SLC7A11
SMCP
SPINT1
SPRY1
STK16
SUSD6
TACSTD2
TCAF1
TFAP2D
TGFB1
THAP7
TNS2
UNC119
UTP23
UXT
VASN
VSTM4
WNT11
XCL2
YIPF3
YY1
ZDHHC1
ZNF330
ZNF414
ZNF417
ZNF440
ZNF446
ZNF497
ZNF587
ZNF696
ZNF764
ZNF786
ZNF837
Entrez ID
3630
81850
HPRD ID
01455
12305
Ensembl ID
ENSG00000254647
ENSG00000221880
Uniprot IDs
I3WAC9
P01308
Q8IUG1
PDB IDs
1A7F
1AI0
1AIY
1B9E
1BEN
1EFE
1EV3
1EV6
1EVR
1FU2
1FUB
1G7A
1G7B
1GUJ
1HIQ
1HIS
1HIT
1HLS
1HTV
1HUI
1IOG
1IOH
1J73
1JCA
1JCO
1JK8
1K3M
1KMF
1LKQ
1LPH
1MHI
1MHJ
1MSO
1OS3
1OS4
1Q4V
1QIY
1QIZ
1QJ0
1RWE
1SF1
1SJT
1SJU
1T0C
1T1K
1T1P
1T1Q
1TRZ
1TYL
1TYM
1UZ9
1VKT
1W8P
1XDA
1XGL
1XW7
1ZEG
1ZEH
1ZNJ
2AIY
2C8Q
2C8R
2CEU
2G54
2G56
2H67
2HH4
2HHO
2HIU
2JMN
2JUM
2JUU
2JUV
2JV1
2JZQ
2K91
2K9R
2KJJ
2KJU
2KQP
2KQQ
2KXK
2L1Y
2L1Z
2LGB
2LWZ
2M1D
2M1E
2M2M
2M2N
2M2O
2M2P
2MLI
2MPG
2MPI
2MVC
2MVD
2N2V
2N2W
2N2X
2OLY
2OLZ
2OM0
2OM1
2OMG
2OMH
2OMI
2OMQ
2QIU
2R34
2R35
2R36
2RN5
2VJZ
2VK0
2W44
2WBY
2WC0
2WRU
2WRV
2WRW
2WRX
2WS0
2WS1
2WS4
2WS6
2WS7
3AIY
3BXQ
3E7Y
3E7Z
3EXX
3FQ9
3HYD
3I3Z
3I40
3ILG
3INC
3IR0
3JSD
3KQ6
3P2X
3P33
3Q6E
3ROV
3TT8
3U4N
3UTQ
3UTS
3UTT
3V19
3V1G
3W11
3W12
3W13
3W7Y
3W7Z
3W80
3ZI3
3ZQR
3ZS2
3ZU1
4AIY
4AJX
4AJZ
4AK0
4AKJ
4CXL
4CXN
4CY7
4EFX
4EWW
4EWX
4EWZ
4EX0
4EX1
4EXX
4EY1
4EY9
4EYD
4EYN
4EYP
4F0N
4F0O
4F1A
4F1B
4F1C
4F1D
4F1F
4F1G
4F4T
4F4V
4F51
4F8F
4FG3
4FKA
4GBC
4GBI
4GBK
4GBL
4GBN
4IUZ
4IYD
4IYF
4NIB
4OGA
4P65
4RXW
4UNE
4UNG
4UNH
4WDI
4XC4
4Y19
4Y1A
4Z76
4Z77
4Z78
5AIY
5BOQ
5BPO
5BQQ
5BTS
5C0D
5CJO
5CNY
5CO2
5CO6
5CO9
5E7W
5EMS
5EN9
5ENA
5HPR
5HPU
5HQI
5HRQ
5HYJ
5MAM
5MHD
5MT3
5MT9
5MWQ
5T7R
5UDP
5UOZ
5UQA
5URT
5URU
5USP
5USS
5USV
5UU2
5UU3
5UU4
5VIZ
5WBT
5WDM
5WOB
6B3Q
6B70
6BFC
6CE7
6CE9
6CEB
6CK2
6GNQ
6GV0
6H3M
6HN5
6JK8
6JR3
6K59
6NWV
6O17
6P4Z
6S34
6S4I
6S4J
6SOF
6TYH
6U46
6VEP
6VET
6X4X
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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