IDO1 and DCTN6

Data Source:
BioGRID (biochemical)

		IDO1	DCTN6
Description		indoleamine 2,3-dioxygenase 1	dynactin subunit 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol Smooth Muscle Contractile Fiber Stereocilium Bundle	Condensed Chromosome Kinetochore Centrosome Cytosol Dynactin Complex
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Electron Transfer Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding	Dynein Complex Binding
	Biological Process	Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Type 2 Immune Response Tryptophan Catabolic Process Inflammatory Response Female Pregnancy Tryptophan Catabolic Process To Kynurenine Electron Transport Chain Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Multicellular Organismal Response To Stress Kynurenic Acid Biosynthetic Process 'de Novo' NAD Biosynthetic Process From Tryptophan Swimming Behavior Negative Regulation Of T Cell Proliferation Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		Tryptophan catabolism	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs		Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood protein levels ( 29875488)	Breast size ( 27182965)
Interacting Genes		5 interacting genes: APP DDX24 FBXL17 PPP1R16A TERF2IP	7 interacting genes: APP CDK1 ERRFI1 HSPB2 NCOA3 PMEPA1 RPSA
Entrez ID		3620	10671
HPRD ID		00935	09907
Ensembl ID		ENSG00000131203	ENSG00000104671
Uniprot IDs		A0A348GSI3 P14902	O00399
PDB IDs		2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PU7 6PZ1 6R63 6TUE 6V52 6WJY	3TV0
Enriched GO Terms of Interacting Partners?
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