IL12B and IL12RB2

Data Source:
HPRD (in vivo)

		IL12B	IL12RB2
Description		interleukin 12B	interleukin 12 receptor subunit beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cytosol External Side Of Plasma Membrane Late Endosome Lumen Receptor Complex Interleukin-12 Complex Interleukin-23 Complex	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Cytokine Binding Interleukin-12 Alpha Subunit Binding Identical Protein Binding Protein-containing Complex Binding Interleukin-23 Receptor Binding Protein Heterodimerization Activity	Cytokine Receptor Activity Cytokine Binding
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Natural Killer Cell Activation Involved In Immune Response Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Cycle Arrest Cell Population Proliferation Response To UV-B Positive Regulation Of Activation Of Janus Kinase Activity Cell Migration Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Sexual Reproduction Natural Killer Cell Activation Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway T-helper 1 Type Immune Response T-helper Cell Differentiation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling
Drugs		5-Mercapto-2-Nitro-Benzoic Acid Briakinumab Ustekinumab Ustekinumab humanized SMART Anti-IL-12 Antibody Tapinarof Tildrakizumab Risankizumab
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Ankylosing spondylitis ( 23749187 21743469) Blood protein levels ( 30072576 29875488) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 28067908 17554261 20570966 21102463 32581322) Cutaneous psoriasis ( 26626624) Inflammatory bowel disease ( 28067908 26278503 23128233) interleukin 12 receptor subunit beta-1 levels ( 25147954) Leprosy ( 32421744 25642632) Multiple sclerosis ( 22190364 21833088) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761 25903422 20953188 20953190 23143594 19169254 19169255) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Response to taxane treatment (placlitaxel) ( 23006423) Sarcoidosis ( 26051272) Serum sulfate level ( 27412988) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 21297633)	Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576 29875488) Crohn's disease ( 28067908 22412388) Crohn's disease or systemic sclerosis ( 32024964) Inflammatory bowel disease ( 28067908 23128233) Medication use (thyroid preparations) ( 31015401) Primary biliary cholangitis ( 19458352 21399635 20639880 26394269) Rheumatoid arthritis ( 32868391) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Systemic lupus erythematosus ( 33536424 26502338 28714469 19838195) Systemic sclerosis ( 31672989 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 28067908)
Interacting Genes		3 interacting genes: IL12A IL12RB1 IL12RB2	5 interacting genes: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		3593	3595
HPRD ID		01194	03383
Ensembl ID		ENSG00000113302	ENSG00000081985
Uniprot IDs		P29460	A0A0A0MTN7 B4DGA4 B7ZB60 Q99665
PDB IDs		1F42 1F45 3D85 3D87 3DUH 3HMX 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD 6UIB
Enriched GO Terms of Interacting Partners?
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