IL9R and IL2RG

Data Source:
HPRD (in vivo)

		IL9R	IL2RG
Description		interleukin 9 receptor	interleukin 2 receptor subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Interleukin-9 Receptor Activity	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity
	Biological Process	Signal Transduction Interleukin-9-mediated Signaling Pathway Regulation Of Cell Population Proliferation	MAPK Cascade Immune Response Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Interleukin-9 signaling	Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Resatorvid
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Interacting Genes		6 interacting genes: CRADD IL2RG IL9 JAK1 KAT5 YWHAZ	27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		3581	3561
HPRD ID		02052	02391
Ensembl ID		ENSG00000124334	ENSG00000147168
Uniprot IDs		Q01113	P31785
PDB IDs			1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL
Enriched GO Terms of Interacting Partners?
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