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RBPJ and HSPB1
Data Source:
BioGRID
(two hybrid)
RBPJ
HSPB1
Description
recombination signal binding protein for immunoglobulin kappa J region
heat shock protein family B (small) member 1
Image
GO Annotations
Cellular Component
Chromatin
MAML1-RBP-Jkappa- ICN1 Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Transcription Repressor Complex
Proteasome Complex
Extracellular Space
Nucleus
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Focal Adhesion
Extracellular Exosome
Axon Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Sequence-specific DNA Binding
Protein N-terminus Binding
Repressing Transcription Factor Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
Protein Folding Chaperone
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Somitogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Inflammatory Response To Antigenic Stimulus
Secondary Heart Field Specification
Outflow Tract Morphogenesis
Endocardium Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cardiac Left Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Humoral Immune Response
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Negative Regulation Of Cell Population Proliferation
Auditory Receptor Cell Fate Commitment
Epidermal Cell Fate Specification
Positive Regulation Of Gene Expression
Pituitary Gland Development
B Cell Differentiation
Keratinocyte Differentiation
Negative Regulation Of Ossification
Positive Regulation Of BMP Signaling Pathway
Somatic Stem Cell Population Maintenance
Dorsal Aorta Morphogenesis
Atrioventricular Canal Development
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Negative Regulation Of Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Timing Of Cell Differentiation
Sebaceous Gland Development
Hair Follicle Maturation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Ventricular Septum Morphogenesis
Club Cell Differentiation
Labyrinthine Layer Blood Vessel Development
Arterial Endothelial Cell Fate Commitment
Notch Signaling Involved In Heart Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Blood Vessel Lumenization
Blood Vessel Endothelial Cell Fate Specification
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of ERBB Signaling Pathway
Positive Regulation Of Ephrin Receptor Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Retina Homeostasis
Regulation Of Protein Phosphorylation
Regulation Of Translational Initiation
Negative Regulation Of Protein Kinase Activity
Response To Unfolded Protein
Response To Virus
Regulation Of Autophagy
Viral Process
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Tumor Necrosis Factor Production
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of MRNA Stability
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Chaperone-mediated Protein Folding
Platelet Aggregation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Anterograde Axonal Protein Transport
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
VEGFA-VEGFR2 Pathway
AUF1 (hnRNP D0) binds and destabilizes mRNA
MAPK6/MAPK4 signaling
Extra-nuclear estrogen signaling
Drugs
Apatorsen
Artenimol
Phenethyl Isothiocyanate
Diseases
Distal hereditary motor neuropathies (dHMN)
GWAS
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
Autoimmune traits (pleiotropy) (
30572963
)
Heel bone mineral density (
30598549
)
Medication use (thyroid preparations) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Rheumatoid arthritis (
24449572
23143596
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Triglyceride levels (
32203549
32154731
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Schizophrenia (
30285260
)
Interacting Genes
28 interacting genes:
APP
CCNF
CIR1
FHL1
GADD45A
GSK3B
HDAC1
HMGB1
HSPB1
KAT2A
KAT2B
MAML1
MED27
NCOR1
NCOR2
NOTCH1
NOTCH2
NOTCH3
NOTCH4
PTF1A
RPS6KA6
SIN3A
SND1
SNW1
SPEN
SPOP
SUFU
TP53
254 interacting genes:
ACAP2
ACBD6
ACTC1
ACTN1
ACTN2
ACTN4
ADCY9
ADD3
ADPRS
AGAP10P
AGAP3
AGAP4
AGAP5
AGAP7P
AKT1
ALPI
AMD1
ANAPC7
ANK1
ANKRD7
ANXA1
AP2B1
APPL1
ARHGAP28
ARHGEF7
ARIH1
ARMT1
ARRDC5
ATXN10
BAG3
BICDL1
BVES
C11orf98
C2orf73
CAMK1
CBX1
CCDC32
CCDC70
CCHCR1
CCNC
CCNDBP1
CCNO
CDC123
CDK5RAP3
CENPK
CEP78
CETN3
CFAP251
CLCN3
CPSF3
CRNKL1
CRYAA
CRYAB
CRYBB2
CRYGC
CS
CYCS
DAXX
DES
DMAP1
DNAJC21
ECPAS
EHD1
EIF1AX
EIF2S1
EIF3M
EIF4G1
EIF4G3
EIF5
ENPP2
EPB41L1
EPB41L2
EPB41L3
ERCC5
ERICH6
ESR1
FAM71D
FLNB
FXR1
GAPVD1
GDI2
GLMN
GNPAT
GOLGA8A
GRIPAP1
GRK3
GSTO1
GTSF1
GUCA1A
HAUS8
HDLBP
HECTD1
HNRNPA2B1
HNRNPD
HNRNPF
HNRNPU
HSP90AB1
HSPA4
HSPA5
HSPB8
HUWE1
IARS2
IGBP1
IGSF21
INPP5K
INS
ISG20L2
KANSL1
KCMF1
KCTD3
KLC1
KNSTRN
KPNA3
KRT18
KRT72
LBP
LIG1
LONRF1
LRIF1
LSM3
LUZP1
MAPK14
MAPKAPK2
MAPKAPK3
MAPKAPK5
MAPT
MCM6
MDH2
MED31
MFAP1
MPHOSPH6
MRGBP
MRPL28
MRPL40
MRPS23
MSL1
MTIF2
MYG1
MYL12A
MYL12B
MYL9
MYLK
NAP1L1
NAPA
NBAS
NCKIPSD
NEK10
NEXN
NFKBIA
NFU1
NSMCE4A
NVL
OBSL1
OPTN
OSBPL9
PAF1
PALM3
PELO
PGM2
PHYHIPL
PLG
PNISR
PNPT1
POP7
PPA1
PPM1A
PPP2R3C
PRPF19
PRPF40A
PSMA3
PSMA6
PSMB2
PSMC1
PSMD1
PTGES3
PTPN3
PTPRA
RAB41
RAD23A
RALA
RASSF9
RBM25
RBM39
RBM48
RBPJ
RPAP3
RPSA
RSPH3
RYBP
S100A4
SAT1
SBF1
SEC13
SERTAD1
SF3A3
SF3B3
SLC7A9
SMARCA2
SMARCA4
SMARCD1
SNRNP200
SNRPF
SPACA7
SPATA7
SPIN1
SPTBN1
SQSTM1
SRP72
STUB1
SUMO2
SUPT5H
SYCE1
TARBP2
TARS1
TBC1D1
TBC1D3B
TGFB1I1
TGM1
THOC5
TJP2
TMCO3
TOMM70
TOX4
TP53
TPT1
TRIM24
TRIM54
TRIM55
TRIM63
TSNAXIP1
TTC3
TTC39C
TXNL1
UCHL5
UFD1
UQCC2
UQCRB
VIM
WASHC3
WDR83
WWP1
XPO1
XRCC5
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
ZBTB17
ZBTB37
ZFAT
ZNF131
ZNF197
ZNRF3
Entrez ID
3516
3315
HPRD ID
00920
09076
Ensembl ID
ENSG00000168214
ENSG00000106211
Uniprot IDs
Q06330
P04792
V9HW43
PDB IDs
2F8X
3NBN
3V79
6PY8
2N3J
3Q9P
3Q9Q
4MJH
6DV5
6GJH
Enriched GO Terms of Interacting Partners
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