APOH and LRP8

Data Source:
HPRD (in vivo)

		APOH	LRP8
Description		apolipoprotein H	LDL receptor related protein 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Platelet Dense Granule Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Microtubule Associated Complex Plasma Membrane Caveola Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Identical Protein Binding Lipoprotein Lipase Activator Activity	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Cargo Receptor Activity Reelin Receptor Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Platelet Degranulation Triglyceride Metabolic Process Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Myeloid Cell Apoptotic Process Triglyceride Transport Negative Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Lipoprotein Lipase Activity Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Signal Transduction Chemical Synaptic Transmission Cytokine-mediated Signaling Pathway Ventral Spinal Cord Development Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Regulation Of Apoptotic Process Regulation Of Innate Immune Response Dendrite Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways		Platelet degranulation	Platelet sensitization by LDL Retinoid metabolism and transport
Drugs		LJP 1082 Copper
Diseases
GWAS		β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Activated partial thromboplastin time ( 29403010) Apolipoprotein B levels ( 32203549) Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Blood protein levels ( 29875488 28240269) Brain morphology (MOSTest) ( 32665545) Cardiometabolic and hematological traits ( 27668658) Coronary artery disease ( 29212778) Creatine kinase levels ( 29403010) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Presence of antiphospholipid antibodies ( 27098658) Systolic blood pressure ( 30224653) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531)	Blood protein levels ( 30072576) Body mass index (alcohol intake interaction) ( 23192594) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Number of sexual partners ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes nephropathy ( 30566433) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		14 interacting genes: AKT1 ANXA2 CDC42 CLEC4G F10 F12 GEM GRB2 LPA LRP2 LRP8 PLG RBBP6 TP53	21 interacting genes: ANAPC10 APBA2 APOE APOH CLU DAB1 DAB2 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MDK MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		350	7804
HPRD ID		00728	04002
Ensembl ID		ENSG00000091583	ENSG00000157193
Uniprot IDs		A0A384NKM6 P02749	A0A590UJ98 Q14114
PDB IDs		1C1Z 1G4F 1G4G 1QUB 2KRI 3OP8 4JHS 6V06 6V08 6V09	3A7Q 5B4X 5B4Y
Enriched GO Terms of Interacting Partners?
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