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AMIGO2 and CACNA1A
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
AMIGO2
CACNA1A
Description
adhesion molecule with Ig like domain 2
calcium voltage-gated channel subunit alpha1 A
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Plasma Membrane
Integral Component Of Membrane
Nucleus
Cytoplasm
Plasma Membrane
Voltage-gated Calcium Channel Complex
Integral Component Of Membrane
Cell Projection
Neuronal Cell Body
Synapse
Molecular Function
Protein Binding
Amyloid-beta Binding
Voltage-gated Calcium Channel Activity
Protein Binding
High Voltage-gated Calcium Channel Activity
Syntaxin Binding
Metal Ion Binding
Biological Process
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Brain Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Synapse Assembly
Calcium Ion Transport
Positive Regulation Of Cytosolic Calcium Ion Concentration
Chemical Synaptic Transmission
Cell Death
Regulation Of Ion Transmembrane Transport
Regulation Of Insulin Secretion
Modulation Of Chemical Synaptic Transmission
Membrane Depolarization
Calcium Ion Import
Calcium Ion Transmembrane Transport
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Pathways
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion
Drugs
Ergocalciferol
Enflurane
Phenytoin
Spironolactone
Magnesium sulfate
Verapamil
Levomenthol
Loperamide
Bepridil
Ziconotide
Dotarizine
Trimebutine
Benidipine
Cilnidipine
Lacidipine
Manidipine
Butamben
Bioallethrin
Bioallethrin
Bioallethrin
Diseases
Episodic ataxias
Familial or sporadic hemiplegic migraine
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Blood protein levels (
30072576
)
Exfoliation syndrome (
25706626
)
Proteinuria and chronic kidney disease (
26420894
)
Interacting Genes
4 interacting genes:
AMIGO1
AMIGO3
CACNA1A
TMED8
92 interacting genes:
ABCA2
ABI1
ACTN1
ADGRL1
AGRN
ALDOA
AMIGO2
AP2M1
ARHGAP22
BTG3
C1QTNF1
CABP1
CACNB1
CACNB4
CALM2
CALM3
CKAP5
CRIM1
CRMP1
CSNK2B
CYSRT1
DNAJB5
EFEMP1
EFEMP2
EHMT2
EIF3A
FBLN1
GET3
GNB1
GOLGA6L5P
GRN
HECW1
HHATL
HIVEP1
HSPG2
IP6K1
JAG2
KALRN
KHDRBS3
KIAA1191
LAMB1
LLGL1
LRP1
LTBP1
LTBP3
LTBP4
MANBAL
MATK
MATN2
MEGF6
MEGF8
MIA3
MOAP1
NDUFB8
NELFCD
NELL1
NELL2
NOTCH1
NOXA1
OLIG1
PCSK5
PCSK6
PMM1
PPIG
PPM1A
PPP1R12C
PTGDS
PUF60
RBM12B
RIMBP2
RPL31
RPS17
SCP2
SPRY1
SRRM4
SRSF1
SUMF2
SYT1
TAF15
TELO2
TSC22D1
TSPAN7
TSPOAP1
TUBB2B
UQCRC2
VARS1
VPS52
VWF
WBP1
YLPM1
ZCCHC17
ZNF233
Entrez ID
347902
773
HPRD ID
16483
03004
Ensembl ID
ENSG00000139211
ENSG00000141837
Uniprot IDs
A0A024R127
Q86SJ2
A0A087WW63
B5TYJ1
O00555
Q9NS89
PDB IDs
3BXK
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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