CFI and CFH

Data Source:
HPRD (in vitro)

		CFI	CFH
Description		complement factor I	complement factor H
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Metal Ion Binding	Protein Binding Heparin Binding Identical Protein Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Proteolysis Endocytosis Complement Activation, Classical Pathway Viral Process Regulation Of Complement Activation Innate Immune Response	Complement Activation Complement Activation, Alternative Pathway Viral Process Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity
Pathways		Regulation of Complement cascade	Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576 29875488 28240269) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Blood protein levels ( 29875488 28240269) Chronic central serous retinopathy ( 30480742 30073298) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Complement factor H binding to malondialdehyde ( 32321835) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Fuchs's corneal dystrophy ( 28358029) Matrix metalloproteinase-8 levels ( 29212897) Meningococcal disease ( 20694013) Neovascular age-related macular degeneration ( 28703135) Nephropathy ( 21399633) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Serum C3d:C3 ratio (systemic complement activation) ( 29398083) Sub-foveal choroidal thickness ( 29844195) Systemic lupus erythematosus ( 28714469)
Interacting Genes		3 interacting genes: C3 CFH GLP1R	16 interacting genes: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16
Entrez ID		3426	3075
HPRD ID		01955	00601
Ensembl ID		ENSG00000205403	ENSG00000000971
Uniprot IDs		A8K3L0 B4DRF2 G3XAM2 P05156 Q8WW88	A0A024R962 A0A0D9SG88 P08603
PDB IDs		2XRC 5O32	1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT 4ZH1 5NBQ 5O32 5O35 5WTB 6ATG
Enriched GO Terms of Interacting Partners?
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