APOBEC1 and A1CF

Data Source:
HPRD (in vivo, in vitro)

		APOBEC1	A1CF
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 1	APOBEC1 complementation factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex
	Molecular Function	RNA Binding MRNA Binding Cytidine Deaminase Activity Cytosine Deaminase Activity Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Domain Specific Binding Ribonucleoprotein Complex Binding	RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding
	Biological Process	RNA Processing MRNA Processing Lipid Metabolic Process Response To Osmotic Stress Cytidine Deamination Response To Zinc Ion Cytidine To Uridine Editing MRNA Modification Cellular Response To Insulin Stimulus Response To Drug Response To Ethanol Regulation Of Catalytic Activity Response To Calcium Ion Defense Response To Virus DNA Cytosine Deamination DNA Demethylation Negative Regulation Of DNA Methylation-dependent Heterochromatin Assembly Positive Regulation Of MRNA Modification	MRNA Processing Cytidine To Uridine Editing MRNA Modification Protein Stabilization
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 28552196) Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Narcolepsy with cataplexy ( 25986216) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31985003 31578528 23263486) Urate levels in lean individuals ( 25811787)
Interacting Genes		16 interacting genes: A1CF APOBEC2 BAG4 CDK6 CELF2 DNAJB11 DND1 HNRNPF HNRNPK KPNA2 KRTAP19-5 KRTAP6-1 KRTAP6-2 NOTO SYNCRIP UFSP2	26 interacting genes: APOBEC1 C19orf54 C9orf24 CAVIN2 CELF2 CYSRT1 DOK3 ECM1 EIF4G1 FHL2 FHL3 HSPB2 HSPB2-C11orf52 KHSRP KLHDC7B KRT31 KRT34 METTL27 OIP5 PLEKHG4 POGZ REL RIMBP3C SYNCRIP TNPO2 TRAF1
Entrez ID		339	29974
HPRD ID		02531	10627
Ensembl ID		ENSG00000111701	ENSG00000148584
Uniprot IDs		P41238	A0A024QZI9 A0A024QZJ5 A0A024QZM7 B4E1E3 F8W9F8 Q9NQ94
PDB IDs			2CPD
Enriched GO Terms of Interacting Partners?
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