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ICAM4 and ITGAV
Data Source:
HPRD
(in vitro)
ICAM4
ITGAV
Description
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
integrin subunit alpha V
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Lamellipodium Membrane
Filopodium Membrane
Microvillus Membrane
Ruffle Membrane
Integrin Alphav-beta3 Complex
Integrin Alphav-beta5 Complex
Integrin Alphav-beta6 Complex
Integrin Alphav-beta8 Complex
Specific Granule Membrane
Alphav-beta3 Integrin-PKCalpha Complex
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Alphav-beta3 Integrin-HMGB1 Complex
Phagocytic Vesicle
Extracellular Exosome
Molecular Function
Integrin Binding
Virus Receptor Activity
Opsonin Binding
Fibronectin Binding
Protease Binding
Protein Kinase C Binding
Integrin Binding
Voltage-gated Calcium Channel Activity
Protein Binding
Coreceptor Activity
Fibroblast Growth Factor Binding
C-X3-C Chemokine Binding
Insulin-like Growth Factor I Binding
Neuregulin Binding
Metal Ion Binding
Transforming Growth Factor Beta Binding
Extracellular Matrix Binding
Extracellular Matrix Protein Binding
Biological Process
Cell Adhesion
Extracellular Matrix Organization
Regulation Of Immune Response
Cell-cell Adhesion
Angiogenesis
Vasculogenesis
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Cell Adhesion
Cell-matrix Adhesion
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Lipid Storage
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Cell-substrate Adhesion
Negative Regulation Of Lipid Transport
Cell Adhesion Mediated By Integrin
Positive Regulation Of Osteoblast Proliferation
Heterotypic Cell-cell Adhesion
Substrate Adhesion-dependent Cell Spreading
Endodermal Cell Differentiation
Apolipoprotein A-I-mediated Signaling Pathway
Apoptotic Cell Clearance
Neutrophil Degranulation
Positive Regulation Of Cell Adhesion
Viral Entry Into Host Cell
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of Lipoprotein Metabolic Process
Regulation Of Phagocytosis
Leukocyte Migration
Negative Chemotaxis
ERK1 And ERK2 Cascade
Calcium Ion Transmembrane Transport
Transforming Growth Factor Beta Production
Entry Into Host Cell By A Symbiont-containing Vacuole
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Transforming Growth Factor Beta Activation
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Negative Regulation Of Entry Of Bacterium Into Host Cell
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Cross-presentation of particulate exogenous antigens (phagosomes)
Elastic fibre formation
PECAM1 interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
Laminin interactions
Syndecan interactions
Syndecan interactions
ECM proteoglycans
VEGFA-VEGFR2 Pathway
Signal transduction by L1
Neutrophil degranulation
Drugs
Antithymocyte immunoglobulin (rabbit)
Levothyroxine
Diseases
GWAS
Blood protein levels (
30072576
28240269
)
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Left-handedness (
32989287
)
Lung function (FEV1/FVC) (
30804560
)
Microalbuminuria (
26631737
)
Urinary albumin-to-creatinine ratio (
26631737
)
Urinary albumin-to-creatinine ratio in non-diabetics (
26631737
)
Interacting Genes
13 interacting genes:
CREB3
CYSRT1
ITGA4
ITGAM
ITGAV
ITGB1
ITGB2
KRT31
KRT34
MTUS2
NBPF19
NOTCH2NLA
RHAG
33 interacting genes:
ADAM9
ANGPTL3
AUP1
AZGP1
CALR
CCN1
CCN3
CD47
EDIL3
F2R
ICAM4
ITGB1
ITGB3
ITGB5
ITGB6
ITGB8
L1CAM
LGALS3BP
MAPK3
MMP14
MMP2
NID1
P2RY2
PAK4
PDGFRA
PLA2G2A
PLP1
PTK2
PXN
SPP1
TGFB1
THY1
UBC
Entrez ID
3386
3685
HPRD ID
00198
01903
Ensembl ID
ENSG00000105371
ENSG00000138448
Uniprot IDs
Q14773
U5U6P8
L7RXH0
P06756
PDB IDs
1JV2
1L5G
1M1X
1U8C
3IJE
4G1E
4G1M
4MMX
4MMY
4MMZ
4O02
4UM8
4UM9
5FFG
5FFO
5NEM
5NER
5NET
5NEU
6AVQ
6AVR
6AVU
6DJP
6MK0
6MSL
6MSU
6NAJ
6OM1
6OM2
6UJA
6UJB
6UJC
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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