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DUSP29 and PSMB5
Data Source:
BioGRID
(two hybrid)
DUSP29
PSMB5
Description
dual specificity phosphatase 29
proteasome 20S subunit beta 5
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Protein-containing Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Extracellular Exosome
Molecular Function
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
MAP Kinase Phosphatase Activity
Protein Homodimerization Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Biological Process
Inactivation Of MAPK Activity
Protein Dephosphorylation
Peptidyl-tyrosine Dephosphorylation
Glucose Homeostasis
Muscle Cell Differentiation
Negative Regulation Of ERK1 And ERK2 Cascade
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Proteolysis
Regulation Of Cellular Amino Acid Metabolic Process
Response To Oxidative Stress
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Bortezomib
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Carfilzomib
Diseases
GWAS
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Interacting Genes
25 interacting genes:
AATK
ARPC3
ASPA
C17orf75
CNTROB
DDIT4L
EPHA2
ERBB3
GOLGA6A
IGF1R
LMTK2
LNX1
NIF3L1
NOC4L
PICK1
POLR2G
PSMB5
PTK7
RNF40
ROR1
ROR2
SRSF11
STX11
TCF4
TEPSIN
28 interacting genes:
ABCB5
BAG4
CCDC150
CLP1
DUSP29
GAGE12G
GAGE2E
IKBKG
LSM1
NTAQ1
PIK3R1
PLK1
POMP
PRNP
PSMA1
PSMA2
PSMA3
PSMA6
PSMB1
PSMB3
PSMB4
PSMB7
PSMG3
TAP1
TAP2
TCHP
TRAF6
XRN1
Entrez ID
338599
5693
HPRD ID
16846
02629
Ensembl ID
ENSG00000188716
ENSG00000100804
Uniprot IDs
Q68J44
A0A140VJS7
P28074
PDB IDs
2Y96
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5L5W
5L5X
5L5Y
5L5Z
5L60
5L61
5L62
5L63
5L64
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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