ICAM2 and RDX

Data Source:
HPRD (in vitro)

		ICAM2	RDX
Description		intercellular adhesion molecule 2	radixin
Image			No pdb structure
GO Annotations	Cellular Component	Uropod Plasma Membrane Integral Component Of Plasma Membrane Microvillus Membrane Cleavage Furrow	Extracellular Space Plasma Membrane Microvillus Adherens Junction Focal Adhesion Apical Plasma Membrane Lamellipodium Filopodium T-tubule Midbody Cortical Actin Cytoskeleton Cleavage Furrow Cell Tip Extracellular Exosome Cell Periphery
	Molecular Function	Integrin Binding	RNA Binding Actin Binding Protein Binding Cadherin Binding Protein Kinase A Binding ATPase Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion	Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Protein Kinase A Signaling Positive Regulation Of Cell Migration Regulation Of Actin Filament Bundle Assembly Regulation Of Rap Protein Signal Transduction Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of GTPase Activity Apical Protein Localization Establishment Of Protein Localization Negative Regulation Of Cell Size Barbed-end Actin Filament Capping Establishment Of Endothelial Barrier Protein Localization To Plasma Membrane Cellular Response To Thyroid Hormone Stimulus Regulation Of Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Adherens Junction Organization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling	Recycling pathway of L1 Recycling pathway of L1
Drugs			1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS			Cognitive function ( 24684796) Coronary artery disease ( 32469254) Multiple sclerosis ( 31604244)
Interacting Genes		8 interacting genes: ATP13A2 CD209 EZR F2RL1 ITGAM ITGB2 MSN RDX	20 interacting genes: ABCC2 ARHGDIA C1QTNF9 CALM1 CPNE1 CPNE2 CPNE4 DRD3 EZR GNA13 ICAM2 ITGB2 L1CAM LINC01554 PSME3 ROCK1 SLC9A3R1 SLC9A3R2 TSC1 VPS11
Entrez ID		3384	5962
HPRD ID		00888	01534
Ensembl ID		ENSG00000108622	ENSG00000137710
Uniprot IDs		P13598 Q6FHE2	B0YJ88 P35241 Q6PKD3
PDB IDs		1ZXQ
Enriched GO Terms of Interacting Partners?
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