HSPA4 and SENP8

Data Source:
BioGRID (enzymatic study)

		HSPA4	SENP8
Description		heat shock protein family A (Hsp70) member 4	SUMO peptidase family member, NEDD8 specific
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Extracellular Exosome	Cytosol
	Molecular Function	Protein Binding ATP Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Response To Unfolded Protein Protein Insertion Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly	Protein Deubiquitination Post-translational Protein Modification
Pathways		Regulation of HSF1-mediated heat shock response	UCH proteinases Neddylation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Triglyceride levels ( 32203549 31928498 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		70 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A	15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28
Entrez ID		3308	123228
HPRD ID		09025	09784
Ensembl ID		ENSG00000170606	ENSG00000166192
Uniprot IDs		P34932	A8K8D3 Q96LD8
PDB IDs			1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?