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HSF1 and PIM2
Data Source:
BioGRID
(affinity chromatography technology, pull down, imaging technique)
HSF1
PIM2
Description
heat shock transcription factor 1
Pim-2 proto-oncogene, serine/threonine kinase
Image
GO Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
PML Body
Perinuclear Region Of Cytoplasm
Nuclear Stress Granule
Mitotic Spindle Pole
Chaperone Complex
Ribonucleoprotein Complex
Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Heat Shock Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Protein Self-association
Protein Heterodimerization Activity
Hsp90 Protein Binding
Translation Elongation Factor Binding
STAT Family Protein Binding
Sequence-specific Single Stranded DNA Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
DNA Repair
Regulation Of Transcription By RNA Polymerase II
MRNA Processing
Defense Response
Response To Nutrient
Positive Regulation Of Cell Population Proliferation
MRNA Transcription
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Response To Activity
Viral Process
Negative Regulation Of Protein-containing Complex Assembly
Response To Testosterone
Cellular Response To Heat
Cellular Response To Unfolded Protein
Cellular Protein-containing Complex Assembly
Cellular Response To Potassium Ion
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Transport
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Estradiol Stimulus
Cellular Response To Gamma Radiation
Cellular Response To Diamide
Negative Regulation Of Inclusion Body Assembly
Positive Regulation Of Inclusion Body Assembly
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cellular Response To Heat
Positive Regulation Of MRNA Polyadenylation
Negative Regulation Of Neuron Death
Positive Regulation Of Apoptotic DNA Fragmentation
Cellular Response To Sodium Arsenite
Cellular Response To Angiotensin
Positive Regulation Of Microtubule Binding
Cellular Response To Nitroglycerin
Cellular Response To L-glutamine
Response To Hypobaric Hypoxia
Response To Psychosocial Stress
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
G1/S Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Apoptotic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Population Proliferation
Response To Virus
Positive Regulation Of Autophagy
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Protein Stabilization
Pathways
Regulation of HSF1-mediated heat shock response
HSF1 activation
Attenuation phase
HSF1-dependent transactivation
Aggrephagy
Drugs
Bimoclomol
Diseases
GWAS
Dupuytren's disease (
28886342
)
Interacting Genes
51 interacting genes:
CAMK2A
CDC20
CDK6
CEBPB
CHST10
CREBBP
CSNK2A1
DAXX
DNAJB1
EEF1D
ENO2
FILIP1
FKBP4
FKBP5
GSK3A
GTF2A2
GTF2B
HSBP1
HSF2
HSP90AA1
HSP90AB1
HSPA1A
HSPA8
MAPK1
MAPK3
MAPK8
MAPK9
MAPKAPK2
NCOA6
PIM2
PPID
PRKDC
PTGES3
RALBP1
REPS1
RNF20
SMARCA4
STAT1
STUB1
SUB1
SUMO1
SUMO3
SYMPK
TAF1
TAF7
TAF9
TBP
UBE2I
XRCC5
XRCC6
YWHAE
15 interacting genes:
ATXN1
BAD
CUTC
DAPK1
FBH1
FBXO7
GSK3B
HNRNPH3
HSF1
IKBKG
NDUFB8
RPL21
SOCS1
TRIM14
ZNF821
Entrez ID
3297
11040
HPRD ID
00778
02244
Ensembl ID
ENSG00000185122
ENSG00000102096
Uniprot IDs
Q00613
A0A024QYW7
Q9P1W9
PDB IDs
2LDU
5D5U
5D5V
5HDG
5HDN
2IWI
4X7Q
Enriched GO Terms of Interacting Partners
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