PRMT2 and PRMT8

Data Source:
BioGRID (pull down)

		PRMT2	PRMT8
Description		protein arginine methyltransferase 2	protein arginine methyltransferase 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Nucleus Plasma Membrane Anchored Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Estrogen Receptor Binding Progesterone Receptor Binding Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Protein Homodimerization Activity Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding Androgen Receptor Binding	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Protein Methylation Signal Transduction Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of NF-kappaB Transcription Factor Activity Histone Arginine Methylation Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Developmental Cell Growth Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Methylation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Arginine Methylation Regulation Of Protein Binding Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Diverticular disease ( 30177863)	Cardiac Troponin-T levels ( 31014085) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) HDL cholesterol ( 19060911)
Interacting Genes		24 interacting genes: BAG6 CBLB CHEK2 CPSF7 DMRTB1 ESR1 ESR2 FIP1L1 HNRNPA1 HNRNPUL1 NCOA1 NCOA6 PGR PRMT8 PRRC2A PSMB3 RB1 RBM12 RIPK2 RXRA SPAG8 THRB WASL ZNF341	22 interacting genes: CARM1 CEP162 COIL DCAF8 EWSR1 FBL FYN GPATCH2L H4C1 KRTAP6-3 OFCC1 PIK3R1 PLCG1 PPARA PRMT1 PRMT2 SERBP1 SYNCRIP TNPO2 UBL5 VHL ZNF451
Entrez ID		3275	56341
HPRD ID		09060	11029
Ensembl ID		ENSG00000160310	ENSG00000111218
Uniprot IDs		A0A0S2Z3N3 P55345	Q59GT2 Q9NR22
PDB IDs		1X2P	4X41 5DST
Enriched GO Terms of Interacting Partners?
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