HOXA2 and DMPK

Data Source:
BioGRID (two hybrid)

		HOXA2	DMPK
Description		homeobox A2	DM1 protein kinase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Determination Osteoblast Development Regulation Of Transcription By RNA Polymerase II Segment Specification Motor Neuron Axon Guidance Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Rhombomere 2 Development Rhombomere 3 Morphogenesis Brain Segmentation Middle Ear Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Viscerocranium Morphogenesis Cellular Response To Retinoic Acid	Regulation Of Sodium Ion Transport Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Regulation Of Excitatory Postsynaptic Membrane Potential Involved In Skeletal Muscle Contraction Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Synapse Structural Plasticity Regulation Of Cardiac Conduction
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of expression of SLITs and ROBOs	Ion homeostasis
Drugs			Bisindolylmaleimide VIII
Diseases			Myotonic dystrophy (DM)
GWAS		Chronic venous disease ( 28374850) Tonsillectomy ( 27182965 28928442)	Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143)
Interacting Genes		6 interacting genes: DMPK MEIS1 NDE1 PPP1CB RCHY1 UBAC1	18 interacting genes: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4
Entrez ID		3199	1760
HPRD ID		05252	05645
Ensembl ID		ENSG00000105996	ENSG00000104936
Uniprot IDs		O43364	B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013
PDB IDs			1WT6 2VD5
Enriched GO Terms of Interacting Partners?
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