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APAF1 and CYCS
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
APAF1
CYCS
Description
apoptotic peptidase activating factor 1
cytochrome c, somatic
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Cytosol
Protein-containing Complex
Secretory Granule Lumen
Apoptosome
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Protein Phosphatase Type 2A Complex
Nucleus
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Cytosol
Respirasome
Molecular Function
Nucleotide Binding
Protein Binding
ATP Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Heat Shock Protein Binding
Identical Protein Binding
ADP Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Heme Binding
Metal Ion Binding
Biological Process
Response To Hypoxia
Kidney Development
Neural Tube Closure
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Nervous System Development
Aging
Response To Nutrient
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Cardiac Muscle Cell Apoptotic Process
Cell Differentiation
Forebrain Development
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Neutrophil Degranulation
Neuron Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Negative Regulation Of G0 To G1 Transition
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To G1 DNA Damage Checkpoint Signaling
Intrinsic Apoptotic Signaling Pathway
Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of Apoptotic Signaling Pathway
Mitochondrial Electron Transport, Ubiquinol To Cytochrome C
Mitochondrial Electron Transport, Cytochrome C To Oxygen
Protein Dephosphorylation
Apoptotic Process
Mitochondrion Organization
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Cellular Response To Oxidative Stress
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Respiration
Pathways
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Neutrophil degranulation
TP53 Regulates Transcription of Caspase Activators and Caspases
Transcriptional Regulation by E2F6
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Release of apoptotic factors from the mitochondria
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes
Respiratory electron transport
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Drugs
ATP
Minocycline
Protoporphyrin Ix Containing Co
Ferroheme C
Imidazole
Zinc protoporphyrin
Trimethyllysine
Zinc Substituted Heme C
Artenimol
Diseases
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
High density lipoprotein cholesterol levels (
30498476
)
Systemic lupus erythematosus (
19838195
)
Interacting Genes
18 interacting genes:
APIP
AVEN
BCL2L1
BCL2L10
CASP3
CASP4
CASP8
CASP9
CYCS
FAS
FEM1B
HIP1
HSP90AA1
HSPA1A
NLRP1
PPP1CA
TOP1
TRIAP1
22 interacting genes:
AGTPBP1
APAF1
BCL2
BCL2L1
CASP9
COX4I2
CUL9
CYB5A
CYB5R1
CYB5R3
CYC1
FDX1
HSPA8
HSPB1
KRT40
MEOX2
NDOR1
RNF7
SAFB
SNCA
UQCRC1
VDAC2
Entrez ID
317
54205
HPRD ID
03755
00479
Ensembl ID
ENSG00000120868
ENSG00000172115
Uniprot IDs
O14727
G4XXL9
P99999
PDB IDs
1C15
1CWW
1CY5
1Z6T
2P1H
2YGS
3J2T
3JBT
3YGS
4RHW
5JUY
5WVC
5WVE
1J3S
2N3Y
2N9I
2N9J
3NWV
3ZCF
3ZOO
5EXQ
5O10
5TY3
6DUJ
6ECJ
Enriched GO Terms of Interacting Partners
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