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HMGB2 and GZMA
Data Source:
BioGRID
(pull down, enzymatic study)
HPRD
(in vivo, in vitro)
HMGB2
GZMA
Description
high mobility group box 2
granzyme A
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Condensed Chromosome
Extracellular Space
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Immunological Synapse
Extracellular Region
Nucleus
Molecular Function
Four-way Junction DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Protein Domain Specific Binding
Chemoattractant Activity
Non-sequence-specific DNA Binding, Bending
RAGE Receptor Binding
Supercoiled DNA Binding
Serine-type Endopeptidase Activity
Protein Binding
Protein Homodimerization Activity
Biological Process
Positive Regulation Of Endothelial Cell Proliferation
Inflammatory Response To Antigenic Stimulus
DNA Topological Change
Double-strand Break Repair Via Nonhomologous End Joining
Apoptotic DNA Fragmentation
Chromatin Organization
Nucleosome Assembly
Regulation Of Transcription By RNA Polymerase II
Spermatid Nucleus Differentiation
Male Gonad Development
Positive Regulation Of Nuclease Activity
DNA Geometric Change
Response To Lipopolysaccharide
Positive Regulation Of Interferon-beta Production
V(D)J Recombination
Positive Regulation Of DNA Binding
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Response To Steroid Hormone
Regulation Of Neurogenesis
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Positive Chemotaxis
Cell Chemotaxis
Cellular Response To Lipopolysaccharide
Regulation Of Stem Cell Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Apoptotic Process
Immune Response
Response To Bacterium
Cytolysis
Negative Regulation Of Endodeoxyribonuclease Activity
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Negative Regulation Of Oxidoreductase Activity
Proteolysis Involved In Cellular Protein Catabolic Process
Pyroptosis
Granzyme-mediated Programmed Cell Death Signaling Pathway
Cytotoxic T Cell Pyroptotic Process
Pathways
Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS
Interacting Genes
38 interacting genes:
APEX1
APP
AR
ARCN1
C1QBP
CACTIN
CHAF1A
CREBBP
CSNK1A1
EIF1
FBXO7
GZMA
GZMK
H3-3A
HACD3
HDLBP
HMGA1
LZTS1
MIEN1
NAP1L1
NCBP3
NEXN
NR3C1
PGR
PKNOX1
POU2F1
POU2F2
POU3F1
POU5F1
PRKDC
RAG1
SAMM50
SET
TP53
TSNAX
ZNF428
ZNF622
ZNF668
17 interacting genes:
ACTG1
APEX1
GOLGA2
H1-1
H2BC21
HDC
HMGB2
HNRNPK
HSP90AA1
HSPA4
LMNA
LMNB1
NCL
NDUFS3
SET
XRCC5
XRCC6
Entrez ID
3148
3001
HPRD ID
01229
00771
Ensembl ID
ENSG00000164104
ENSG00000145649
Uniprot IDs
P26583
P12544
PDB IDs
1HF1
1OP8
1ORF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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