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HMGB1 and POU5F1
Data Source:
HPRD
(in vitro, in vivo)
HMGB1
POU5F1
Description
high mobility group box 1
POU class 5 homeobox 1
Image
GO Annotations
Cellular Component
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Early Endosome
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cell Surface
Transcription Repressor Complex
Secretory Granule Lumen
Alphav-beta3 Integrin-HMGB1 Complex
Neuron Projection
Ficolin-1-rich Granule Lumen
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Molecular Function
Four-way Junction DNA Binding
Bubble DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Lipopolysaccharide Binding
Phosphatidylserine Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Cytokine Activity
Integrin Binding
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Calcium-dependent Protein Kinase Regulator Activity
Lyase Activity
C-X-C Chemokine Binding
Protein Kinase Activator Activity
Chemoattractant Activity
RAGE Receptor Binding
DNA Polymerase Binding
Repressing Transcription Factor Binding
Supercoiled DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Ubiquitin Protein Ligase Binding
MiRNA Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Eye Development
Myeloid Dendritic Cell Activation
Endothelial Cell Proliferation
Activation Of Innate Immune Response
Toll-like Receptor Signaling Pathway
Plasmacytoid Dendritic Cell Activation
Macrophage Activation Involved In Immune Response
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
Regulation Of Tolerance Induction
Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA Topological Change
Base-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Apoptotic DNA Fragmentation
DNA Recombination
Chromatin Silencing
Regulation Of Transcription By RNA Polymerase II
Autophagy
Inflammatory Response
Positive Regulation Of Cytosolic Calcium Ion Concentration
Positive Regulation Of Autophagy
Viral Process
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Lung Development
Neuron Projection Development
Chromatin Assembly
Regulation Of Restriction Endodeoxyribonuclease Activity
Activation Of Protein Kinase Activity
DNA Geometric Change
Positive Regulation Of Mismatch Repair
Tumor Necrosis Factor Production
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
V(D)J Recombination
Positive Regulation Of Toll-like Receptor 2 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 9 Signaling Pathway
T-helper 1 Cell Activation
Endothelial Cell Chemotaxis
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
T-helper 1 Cell Differentiation
Innate Immune Response
Positive Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Glycogen Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Chemotaxis
Positive Regulation Of DNA Ligation
Response To Glucocorticoid
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Wound Healing
Neutrophil Clearance
Cellular Response To Interleukin-7
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Negative Regulation Of Apoptotic Cell Clearance
Regulation Of Nucleotide-excision Repair
Positive Regulation Of Dendritic Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Endodermal Cell Fate Specification
Blastocyst Development
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Response To Wounding
Anatomical Structure Morphogenesis
Regulation Of Asymmetric Cell Division
Regulation Of Gene Expression
Somatic Stem Cell Population Maintenance
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Gene Silencing By MiRNA
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways
Apoptosis induced DNA fragmentation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Drugs
Chloroquine
Ethyl pyruvate
Diseases
GWAS
Adult body size (
32376654
)
Apolipoprotein A1 levels (
32203549
)
Blood osmolality (transformed sodium) (
28360221
)
Carotid plaque burden (
28282560
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Hippocampal volume (
21116278
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Red blood cell count (
32888494
)
Triglyceride levels (
32203549
32154731
)
Type 2 diabetes (
30297969
)
Urate levels (
31578528
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Cold sores (
28928442
)
Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) (
21801394
)
Epstein-Barr virus copy number in lymphoblastoid cell lines (
28654678
)
Inflammatory bowel disease (
28067908
)
Lymphocyte counts (
27863252
)
Malaria (
31844061
)
Multiple myeloma (
23955597
)
Night sleep phenotypes (
27126917
)
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) (
21912425
)
Type 2 diabetes (
24509480
30718926
28869590
)
Ulcerative colitis (
28067908
)
Interacting Genes
96 interacting genes:
ACBD3
AGER
AGTRAP
AR
ATOH1
C1QBP
C3
CASP3
CCAR1
CCNDBP1
CDK1
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CTNNBL1
CUX1
DNM2
DNMT1
DUX4
EIF1
ENAH
EP300
ERF
ERG28
FIP1L1
FOXA3
FOXC1
GTF2A1
HES1
HMGA1
HNRNPK
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HPF1
HR
HSPA5
IRF2
KRT7
LRIF1
MECP2
MNT
MT2A
NCAN
NEUROD6
NEXN
NFKB1
NR3C1
PCOLCE
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PTPRZ1
RAD23B
RAG1
RASSF4
RB1
RBPJ
RELA
RFX1
RPL29
RPS12
RPS20
SIX5
SOX18
SPINT1
TAF1
TBP
TERF2
TERF2IP
TFE3
TGIF1
TLE1
TLE2
TLE5
TLR2
TLR4
TP53
TP73
UBE2I
UNC119
ZFP36
ZNF24
ZNF428
15 interacting genes:
AR
ETS2
EWSR1
FOXD3
HMGB1
HMGB2
ITCH
LRRK2
MNAT1
NR0B1
SOX10
SOX2
SOX8
STUB1
WDR5
Entrez ID
3146
5460
HPRD ID
01228
01252
Ensembl ID
ENSG00000189403
ENSG00000204531
Uniprot IDs
A0A024RDR0
P09429
D2IYK3
F2Z381
M1S623
Q01860
PDB IDs
2LY4
2RTU
2YRQ
6CG0
6CIJ
6CIK
6CIL
6CIM
6OEM
6OEN
6OEO
6T90
6YOV
Enriched GO Terms of Interacting Partners
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