HLA-DRA and HLA-DMA

Data Source:
HPRD (in vitro, in vivo)

		HLA-DRA	HLA-DMA
Description		major histocompatibility complex, class II, DR alpha	major histocompatibility complex, class II, DM alpha
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GO Annotations	Cellular Component	Golgi Membrane Immunological Synapse Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Lysosomal Membrane Cell Surface Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Polysaccharide Binding MHC Class II Receptor Activity Peptide Antigen Binding T Cell Receptor Binding	Protein Binding MHC Class II Protein Complex Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Myeloid Dendritic Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Regulation Of T-helper Cell Differentiation T Cell Receptor Signaling Pathway Cognition Interferon-gamma-mediated Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation	Adaptive Immune Response Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs		1D09C3 Coccidioides immitis spherule
Diseases			Allograft rejection
GWAS		Acute-on-chronic liver failure in hepatitis B ( 28130311) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Anti-cyclic Citrullinated Peptide Antibody ( 19287509) Antinuclear antibody levels ( 25186300) Apolipoprotein B levels ( 32203549) Asthma ( 23028483 21804548 30929738 31619474 29273806) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body mass index ( 28892062) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cardiometabolic and hematological traits ( 27668658) Chloride levels ( 29403010) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 23850713) Cystic fibrosis severity ( 21602797) Endometriosis ( 28881265) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262) Estimated glomerular filtration rate in diabetes ( 31451708) Feeling worry ( 29500382) Fibrinogen levels ( 28107422) Food antigen IgG levels ( 24962563) Frontotemporal dementia ( 24943344) Giant cell arteritis ( 28041642) Hepatitis B ( 28928442) Hepatitis B vaccine response ( 24282030) HIV-1 viral setpoint ( 26039976) Hodgkin's lymphoma ( 21037568 22286212) Inflammatory bowel disease ( 28008999 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung disease severity in cystic fibrosis ( 26417704) Lymphoma ( 23349640) Multiple sclerosis ( 17660530) Multiple sclerosis (OCB status) ( 23472185) Nodular sclerosis Hodgkin lymphoma ( 29196614) Non-obstructive azoospermia ( 22541561) Obstetric antiphospholipid syndrome ( 28424481) Parkinson's disease ( 20711177) Perceived unattractiveness to mosquitoes ( 28199695) Primary biliary cholangitis ( 28425483 28062665) Primary central nervous system lymphoma ( 31102405) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Response to hepatitis B vaccine ( 29534301) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Sarcoidosis (non-Lofgren's syndrome) ( 26651848) SjÃ¶gren's syndrome ( 24097066 24097067) Staphylococcus aureus infection ( 26450422) Systemic juvenile idiopathic arthritis ( 27927641) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Tuberculosis ( 29036319) Ulcerative colitis ( 28008999 24837172 28067908 23128233 20228798 18836448 21297633 19122664) Urate levels ( 31578528) Vitiligo ( 20410501) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist circumference adjusted for body mass index ( 28552196) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)
Interacting Genes		11 interacting genes: CD63 CD74 CD82 HLA-DMA HLA-DMB HLA-DRB1 HLA-DRB5 MARCHF1 MBP PRPF40B TLR3	8 interacting genes: B3GAT1 CD74 CD82 HLA-DMB HLA-DOA HLA-DRA HLA-DRB1 U2AF2
Entrez ID		3122	3108
HPRD ID		00833	00830
Ensembl ID		ENSG00000204287	ENSG00000204257
Uniprot IDs		A0A0G2JMH6 P01903	Q31604 Q6ICR9
PDB IDs		1A6A 1AQD 1BX2 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1FYT 1H15 1HQR 1HXY 1J8H 1JWM 1JWS 1JWU 1KG0 1KLG 1KLU 1LO5 1PYW 1R5I 1SEB 1SJE 1SJH 1T5W 1T5X 1YMM 1ZGL 2FSE 2G9H 2IAM 2IAN 2ICW 2IPK 2OJE 2Q6W 2SEB 2WBJ 2XN9 3C5J 3L6F 3O6F 3PDO 3PGC 3PGD 3QXA 3QXD 3S4S 3S5L 3T0E 4AEN 4AH2 4C56 4E41 4FQX 4GBX 4H1L 4H25 4H26 4I5B 4IS6 4MCY 4MCZ 4MD0 4MD4 4MD5 4MDI 4MDJ 4OV5 4X5W 4X5X 4Y19 4Y1A 5JLZ 5LAX 5NI9 5NIG 5V4M 5V4N 6ATF 6ATI 6ATZ 6BIJ 6BIL 6BIN 6BIR 6BIV 6BIX 6BIY 6BIZ 6CPL 6CPN 6CPO 6CQJ 6CQL 6CQN 6CQQ 6CQR 6NIX 6QZA 6QZC 6QZD 6R0E	4I0P
Enriched GO Terms of Interacting Partners?
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