HLA-DMB and CD63

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HLA-DMB	CD63
Description		major histocompatibility complex, class II, DM beta	CD63 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Integral Component Of Membrane Late Endosome Membrane MHC Class II Protein Complex Intracellular Membrane-bounded Organelle	Extracellular Space Nucleoplasm Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Multivesicular Body Membrane Azurophil Granule Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome Multivesicular Body, Internal Vesicle
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding	Protein Binding
	Biological Process	Adaptive Immune Response MHC Class II Protein Complex Assembly Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Positive Regulation Of Receptor Internalization Platelet Degranulation Cell-matrix Adhesion Protein Transport Cell Migration Cellular Protein Localization Endosome To Melanosome Transport Neutrophil Degranulation Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		MHC class II antigen presentation	Platelet degranulation Neutrophil degranulation
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Dermatomyositis ( 27153935) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Squamous cell lung carcinoma ( 28604730)	Advanced age-related macular degeneration ( 26691988) Cardiac Troponin-T levels ( 31014085) Refractive error ( 32231278)
Interacting Genes		11 interacting genes: CD63 CD74 CD82 CUL3 DPM2 HLA-DMA HLA-DOB HLA-DRA MDM2 PSEN2 TEAD1	18 interacting genes: AP4M1 CD82 CD9 F2RL1 GLP1R HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SLC22A1 SLC22A2 SRF TIMP1 TMEM80 VKORC1
Entrez ID		3109	967
HPRD ID		00831	01121
Ensembl ID		ENSG00000242574	ENSG00000135404
Uniprot IDs		A0A1V0E3P2 P28068	A0A024RB05 P08962
PDB IDs		1HDM 2BC4 4FQX 4GBX 4I0P
Enriched GO Terms of Interacting Partners?
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