HK1 and ENO2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HK1	ENO2
Description		hexokinase 1	enolase 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Raft	Phosphopyruvate Hydratase Complex Photoreceptor Inner Segment Extracellular Space Cytosol Plasma Membrane Membrane Perikaryon Extracellular Exosome
	Molecular Function	Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity Identical Protein Binding Peptidoglycan Binding	Magnesium Ion Binding Phosphopyruvate Hydratase Activity Protein Binding
	Biological Process	Cellular Glucose Homeostasis Positive Regulation Of Cytokine Production Involved In Immune Response Fructose 6-phosphate Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion	Gluconeogenesis Glycolytic Process Regulation Of Vacuole Fusion, Non-autophagic Canonical Glycolysis
Pathways		Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis	Glycolysis Gluconeogenesis
Drugs		alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine	2-Phosphoglycolic Acid
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Glycated hemoglobin levels ( 20858683 31213470 19096518 28898252) Glycemic traits (pregnancy) ( 23903356) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494 27863252 19862010) Hemoglobin ( 32888494 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Ischemic stroke (cardioembolic) ( 29531354) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494 20139978 27863252) Mean corpuscular volume ( 32888494 20139978 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Red blood cell count ( 32888494 20139978 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		5 interacting genes: APP ENO2 SCMH1 VDAC1 VDAC2	25 interacting genes: A2M ACD AKT1 ANXA11 BMERB1 C6orf47 ENSA EXOC5 HABP4 HK1 HSF1 IL17B MAP4 MTNR1A NAT9 NDUFS7 POT1 SIGIRR SNUPN ST3GAL2 SUMO4 TERF1 TINF2 TUBA4A UBE2C
Entrez ID		3098	2026
HPRD ID		00809	00573
Ensembl ID		ENSG00000156515	ENSG00000111674
Uniprot IDs		A0A024QZK7 A8K7J7 B3KXY9 P19367 P78542 Q59FD4	P09104 Q6FHV6
PDB IDs		1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB	1TE6 2AKM 2AKZ 3UCC 3UCD 3UJE 3UJF 3UJR 3UJS 4ZA0 4ZCW 5EU9 5IDZ 5TD9 5TIJ
Enriched GO Terms of Interacting Partners?
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