HGF and HPN

Data Source:
HPRD (in vitro)

		HGF	HPN
Description		hepatocyte growth factor	hepsin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Protein-containing Complex Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Serine-type Exopeptidase Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Mitotic Cell Cycle Cell Morphogenesis Epithelial To Mesenchymal Transition Liver Development Positive Regulation Of Protein Phosphorylation Platelet Degranulation Proteolysis Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Animal Organ Regeneration Positive Regulation Of Myelination Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Growth Factor Receptor Signaling Pathway Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of P38MAPK Cascade Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Tau-protein Kinase Activity Positive Regulation Of DNA Biosynthetic Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Transcription Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation
Pathways		Platelet degranulation PIP3 activates AKT signaling Interleukin-7 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3	MET Receptor Activation Signaling by MST1
Drugs		Heparin O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine ABT-510 Foretinib	Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Endothelial growth factor levels ( 25552591) Gestational age at birth (maternal effect) ( 28598419) Gout ( 22179738) Gout (normal type) ( 32238385) Hepatocyte growth factor levels ( 27989323 25998175) Intraocular pressure ( 29785010 29235454) Rosacea symptom severity ( 29771307) Spontaneous preterm birth (maternal effect) ( 28598419) Transverse temporal cortex volume ( 31530798) Tuberculosis ( 29036319)	C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum albumin level ( 23022100) Serum total protein level ( 29403010) Triglyceride levels ( 32203549 32154731) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in diabetes ( 31511532)
Interacting Genes		37 interacting genes: ADAMTSL4 ARNT BRCA1 CCND2 CDK4 CDK6 CDKN2A CDKN2B CLEC3B EPHA2 ERBB2 F11 FGFR4 FN1 GLIS2 HGFAC HPN KLKB1 LATS2 LCN2 MAP2K5 MAP2K6 MDM4 MEOX2 MET MYC NF2 PDGFRA PLAU RAF1 SDC1 SDC2 ST14 STK11 TEAD2 VTN YWHAG	7 interacting genes: BNIP3 EGFR F7 GLP1R HGF SFTPC UPK2
Entrez ID		3082	3249
HPRD ID		00799	00801
Ensembl ID		ENSG00000019991	ENSG00000105707
Uniprot IDs		P14210	A0A140VJK9 B7Z1L4 P05981
PDB IDs		1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4D3C 4K3J 4O3T 4O3U 5COE 5CP9 5CS1 5CS3 5CS5 5CS9 5CSQ 5CT1 5CT2 5CT3	1O5E 1O5F 1P57 1Z8G 3T2N 5CE1
Enriched GO Terms of Interacting Partners?
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