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HEXB and FAM210B
Data Source:
BioGRID
(two hybrid)
HEXB
FAM210B
Description
hexosaminidase subunit beta
family with sequence similarity 210 member B
Image
No pdb structure
GO Annotations
Cellular Component
Acrosomal Vesicle
Extracellular Region
Membrane
Azurophil Granule Lumen
Azurophil Granule
Lysosomal Lumen
Extracellular Exosome
Mitochondrion
Mitochondrial Outer Membrane
Integral Component Of Membrane
Intrinsic Component Of Membrane
Molecular Function
Beta-N-acetylhexosaminidase Activity
Protein Binding
Acetylglucosaminyltransferase Activity
Identical Protein Binding
N-acetyl-beta-D-galactosaminidase Activity
Protein Binding
Biological Process
Skeletal System Development
Glycosphingolipid Metabolic Process
Ganglioside Catabolic Process
Cellular Calcium Ion Homeostasis
Lysosome Organization
Penetration Of Zona Pellucida
Sensory Perception Of Sound
Locomotory Behavior
Male Courtship Behavior
Regulation Of Cell Shape
Phospholipid Biosynthetic Process
Oligosaccharide Catabolic Process
Lipid Storage
Chondroitin Sulfate Catabolic Process
Hyaluronan Catabolic Process
Keratan Sulfate Catabolic Process
Myelination
Neutrophil Degranulation
Astrocyte Cell Migration
Cellular Protein Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Oogenesis
Neuromuscular Process Controlling Balance
Erythrocyte Maturation
Positive Regulation Of Erythrocyte Differentiation
Cellular Response To Estradiol Stimulus
Pathways
Glycosphingolipid metabolism
Keratan sulfate degradation
CS/DS degradation
Hyaluronan uptake and degradation
Defective HEXB causes GM2G2
Neutrophil degranulation
Drugs
Pyrimethamine
2-Acetamido-2-Deoxy-D-Glucono-1,5-Lactone
N-Acetyl-glucosamine thiazoline
(2R,3R,4S,5R)-2-acetamido-3,4-dihydroxy-5-hydroxymethyl-piperidine
Diseases
GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS
Gut microbiota relative abundance (unassigned genus belonging to family Clostridiales) (
33208821
)
Metabolite levels (
23823483
)
Night sleep phenotypes (
27126917
)
Interacting Genes
5 interacting genes:
CSNK2B
EIF2D
FAM210B
HOXA1
TMEM14B
62 interacting genes:
ATP6V0B
ATP6V0C
BCL2L13
BET1
C1GALT1
C5orf46
CCDC167
CD300C
CLDND2
CNIH3
CYB5B
CYB5R3
CYP4F2
EMP3
FIS1
FXYD6-FXYD2
GIMAP5
HEXB
HMOX1
HMOX2
IER3IP1
IFITM3
LNPEP
LPAR3
MFF
MS4A13
NINJ2
NKG7
ORMDL2
OTOP3
PLP2
PLPP6
RPRM
RTP2
SERP1
SERP2
SLC16A13
SLC30A8
SLC35B4
SLC35G1
SMCO4
SMIM1
STX6
STX7
SYNJ2BP
TF
TFRC
TIMM23
TIMMDC1
TMEM107
TMEM11
TMEM140
TMEM187
TMEM19
TMIE
UBE2J1
VAMP1
VAMP3
VAMP4
VKORC1
YIF1A
ZDHHC21
Entrez ID
3074
116151
HPRD ID
06043
12737
Ensembl ID
ENSG00000049860
ENSG00000124098
Uniprot IDs
A0A024RAJ6
P07686
Q5URX0
Q96KR6
PDB IDs
1NOU
1NOW
1NP0
1O7A
1QBD
2GJX
2GK1
3LMY
5BRO
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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