HBA1 and KRT31

Data Source:
BioGRID (two hybrid)

		HBA1	KRT31
Description		hemoglobin subunit alpha 1	keratin 31
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Hemoglobin Complex Membrane Cytosolic Small Ribosomal Subunit Haptoglobin-hemoglobin Complex Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Peroxidase Activity Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Haptoglobin Binding Organic Acid Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Receptor-mediated Endocytosis Positive Regulation Of Cell Death Oxygen Transport Bicarbonate Transport Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification	Cytoskeleton Organization Epidermis Development Keratinization Cornification
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Scavenging of heme from plasma	Keratinization Formation of the cornified envelope
Drugs		Iron Dextran Iron Zinc 4-Carboxycinnamic Acid Pentaerythritol tetranitrate 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine Sebacic acid 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID 2,6-dicarboxynaphthalene Efaproxiral Trimesic acid Nitrous acid Copper Ferric pyrophosphate Sodium ferric gluconate complex Ferrous sulfate anhydrous Ferric pyrophosphate citrate Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Zinc chloride Zinc sulfate, unspecified form Voxelotor Ferric derisomaltose
Diseases		Thalassemia; Alpha thalassemia; Beta thalassemia; Alpha thalassemia, X-linked (ATRX)
GWAS		Body mass index ( 26426971) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693 26366553) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 20139978 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)	Brown vs. black hair color ( 30531825)
Interacting Genes		17 interacting genes: ATP6AP1 CRYAB DAXX HBB HBD HBE1 HBG2 HBQ1 KRT31 KRT34 NAP1L1 NBPF19 NOTCH2NLA PTEN SPINK7 UBE3A UCHL5	356 interacting genes: A1CF ABI2 ABI3 ABL1 ACTR10 AGR2 AGXT AIMP2 AKR7A3 ALDH3B1 AMOT AMOTL2 ANKRD36BP1 ANKS1A AQP1 AQP5 ARHGAP35 ARID3A ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 ATXN7L2 AVPI1 B4GALT7 BAD BCAS2 BEX1 BEX2 BFSP2 BHLHA9 BRME1 BTC BYSL C19orf73 C1orf109 C1orf216 C2CD6 C3 C5orf49 C5orf60 CA6 CARD9 CATIP CATSPER1 CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC17 CCDC187 CCDC196 CCDC198 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CDKN2C CDR2L CEP57 CEP57L1 CEP70 CFAP206 CFAP53 CHCHD2 CHRNG CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COMT COX5A COX5B CRACR2A CREB5 CRH CTSG CXCL16 CYSRT1 DEF6 DGCR6L DHX37 DMRT3 DOCK2 DTNB EIF4E2 EIF4G1 ENKD1 EPDR1 EXOC8 EXOSC5 FADS2 FAM110A FAM124B FAM50B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FGF16 FKBP1B FOXB1 FRS3 GAD1 GADD45GIP1 GEM GFAP GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GOLGA6L2 GPS2 GSTP1 HAPLN2 HAUS1 HBA1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB5 HS6ST1 HSD3B7 HSF4 HSPA12B HSPD1 HYAL2 ICAM4 IL16 INPP5D INPP5K INSR ITGB2 ITGB4 ITGB5 JOSD1 KCTD9 KDM1A KIAA1217 KIFC3 KLC1 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP4-12 KRTAP5-6 KRTAP9-2 KRTAP9-3 LATS1 LCE1B LCE3C LCE3D LCE3E LCE4A LENG1 LIF LIN37 LINC00526 LMF2 LMNTD2 LMO3 LMO4 LONRF1 LRRC41 MAB21L2 MAP3K7CL MAPKBP1 MARK4 MID2 MOS MRPL40 MSRB3 MTA1 MXD3 MXI1 MYOM1 NAV1 NAXD NEK6 NODAL NPBWR2 NTAQ1 NUDT16L1 NUFIP2 OTUB2 OTX1 P2RX7 P3H3 PBX3 PDE4DIP PDGFRB PGAP6 PGLS PHC2 PHLDA1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 POLDIP3 POU4F2 POU4F3 PPP1R18 PPP1R32 PRF1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRPH PRR19 PRR35 PSMA1 PSMB1 PSMC5 PSMG2 PSPC1 PTGER3 PTPMT1 R3HDM2 RAB33A RADIL RAMAC RCOR3 RHPN1 RIBC1 RPS19BP1 RPUSD3 RSPH14 RTP5 SAMD11 SCNM1 SEC14L4 SEMA4C SHC3 SHFL SHISA6 SIRPA SLC15A3 SLC23A1 SLC25A42 SLC25A6 SMARCD1 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPG21 SPON2 SPRING1 SPRY1 SRSF2 SSX2IP STK16 TACO1 TAPBPL TCEANC TEAD4 TEPSIN TEX28 TEX33 TFAP2D THAP7 TLE5 TMEM106C TMEM174 TMEM231 TMSB4X TRAF4 TRIML2 TROAP TSEN54 TSG101 TSHZ3 TSNAX TTC23 TTC9C TXLNA TYK2 UACA UBASH3A USHBP1 USP2 UTP23 UXT VASN VPS9D1 WDR25 WFDC6 ZDHHC1 ZFHX3 ZFYVE21 ZGPAT ZIC1 ZNF124 ZNF148 ZNF20 ZNF250 ZNF414 ZNF417 ZNF446 ZNF564 ZNF569 ZNF572 ZNF587 ZNF688 ZNF69 ZNF835 ZNRF2P1
Entrez ID		3039	3881
HPRD ID		00784	03047
Ensembl ID		ENSG00000206172	ENSG00000094796
Uniprot IDs		D1MGQ2 P69905	Q15323
PDB IDs		1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1A9W 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FDH 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1SHR 1SI4 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y01 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 1Z8U 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHB 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HHB 3HXN 3IA3 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3OVU 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S48 3S65 3S66 3SZK 3WCP 3WHM 4FC3 4HHB 4IJ2 4L7Y 4M4A 4M4B 4MQC 4MQG 4MQH 4MQI 4MQJ 4MQK 4N7N 4N7O 4N7P 4N8T 4NI0 4NI1 4ROL 4ROM 4WJG 4X0L 4XS0 5E29 5E6E 5E83 5EE4 5HU6 5HY8 5JDO 5KDQ 5KSI 5KSJ 5NI1 5SW7 5U3I 5UCU 5UFJ 5URC 5VMM 5WOG 5WOH 5X2R 5X2S 5X2T 5X2U 6BB5 6BNR 6BWP 6BWU 6DI4 6HAL 6HBW 6HK2 6KA9 6KAE 6KAH 6KAI 6KAO 6KAP 6KAQ 6KAR 6KAS 6KAT 6KAU 6KAV 6KYE 6L5V 6L5W 6L5X 6L5Y 6LCW 6LCX 6NBC 6NBD 6NQ5 6TB2
Enriched GO Terms of Interacting Partners?
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