HARS1 and TNIK

Data Source:
BioGRID (two hybrid)

		HARS1	TNIK
Description		histidyl-tRNA synthetase 1	TRAF2 and NCK interacting kinase
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Histidine-tRNA Ligase Activity ATP Binding Identical Protein Binding Protein Homodimerization Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation Mitochondrial Translation	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Stress-activated Protein Kinase Signaling Cascade Actin Cytoskeleton Reorganization Activation Of Protein Kinase Activity Intracellular Signal Transduction Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Cytosolic tRNA aminoacylation	Oxidative Stress Induced Senescence
Drugs		Histidine	Fostamatinib
Diseases
GWAS			Adolescent idiopathic scoliosis ( 28334814) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 29274321) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cortical surface area (MOSTest) ( 32665545) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136) Frontotemporal dementia (age at onset) ( 29724592) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 28552196) LDL cholesterol ( 21347282) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Night sleep phenotypes ( 27126917) Response to antipsychotic treatment in schizophrenia ( 29503163) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458)
Interacting Genes		7 interacting genes: EEF1B2 EEF1G MTNR1B PSMC5 RPL5 TARS1 TNIK	37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		3035	23043
HPRD ID		00827	18206
Ensembl ID		ENSG00000170445	ENSG00000154310
Uniprot IDs		B4DDD8 B4E1C5 P12081	Q9UKE5
PDB IDs		1X59 2LW7 4G84 4G85 4PHC 4X5O 5W6M 6O76	2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7
Enriched GO Terms of Interacting Partners?
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