ANXA2 and TENT2

Data Source:
BioGRID (two hybrid)

		ANXA2	TENT2
Description		annexin A2	terminal nucleotidyltransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Lipid Droplet Plasma Membrane Adherens Junction Cell Surface Membrane Basolateral Plasma Membrane Midbody Late Endosome Membrane Vesicle Azurophil Granule Lumen Melanosome Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex PCSK9-AnxA2 Complex	Cytosol Nuclear RNA-directed RNA Polymerase Complex
	Molecular Function	Phosphatidylserine Binding Protease Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Identical Protein Binding S100 Protein Binding Virion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Metal Ion Binding Adenylyltransferase Activity
	Biological Process	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Vesicle Budding From Membrane Negative Regulation Of Endopeptidase Activity Viral Process Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Interleukin-12-mediated Signaling Pathway Osteoclast Development Neutrophil Degranulation Positive Regulation Of Vacuole Organization Negative Regulation Of Development Of Symbiont Involved In Interaction With Host Catabolism By Host Of Symbiont Protein Negative Regulation By Host Of Symbiont Molecular Function Calcium Ion Transmembrane Transport Cell-cell Adhesion Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Receptor Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport	Hematopoietic Progenitor Cell Differentiation MRNA Polyadenylation Hippocampus Development Neuron Differentiation RNA 3'-end Processing RNA Stabilization RNA Polyadenylation Retina Development In Camera-type Eye Histone MRNA Catabolic Process Dark Adaptation Negative Regulation Of MiRNA Catabolic Process
Pathways		Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS		Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)	Leukocyte telomere length ( 32109421)
Interacting Genes		44 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF GRB2 HMGA1 LGALS13 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SMN1 SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TP53 TRPV5 YWHAQ ZBTB4	29 interacting genes: ANXA2 CADPS CALCOCO2 DTX2 KRTAP6-3 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR141 MIR145 MIR155 MIR15B MIR21 MIR222 MIR29A MIR29C MIR34B MIR363 MIR451A MIR9-1 MIR9-2 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7F2 RBPMS
Entrez ID		302	167153
HPRD ID		01061	15098
Ensembl ID		ENSG00000182718	ENSG00000164329
Uniprot IDs		A0A024R5Z7 P07355	D6RAF2 Q6PIY7
PDB IDs		1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY
Enriched GO Terms of Interacting Partners?
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