H1-2 and LEO1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		H1-2	LEO1
Description		H1.2 linker histone, cluster member	LEO1 homolog, Paf1/RNA polymerase II complex component
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination	Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Beta-catenin-TCF Complex Assembly
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Interacting Genes		30 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 SNCA VHL WDR12 WDR5 YBX1	9 interacting genes: BHLHB9 CSNK2A1 CTNNB1 ERCC6 H1-2 PAF1 POLR2A TCEA1 TCEA3
Entrez ID		3006	123169
HPRD ID		07514	11231
Ensembl ID		ENSG00000187837	ENSG00000166477
Uniprot IDs		P16403	Q8WVC0
PDB IDs			4M6T 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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