NRBF2 and PIK3R4

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		NRBF2	PIK3R4
Description		nuclear receptor binding factor 2	phosphoinositide-3-kinase regulatory subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Autophagosome Cytoplasmic Vesicle Phosphatidylinositol 3-kinase Complex, Class III	Late Endosome Autophagosome Cytosol Axoneme Microtubule Cytoskeleton Membrane Phagocytic Vesicle Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Intracellular Membrane-bounded Organelle Nucleus-vacuole Junction
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Autophagy Response To Endoplasmic Reticulum Stress Regulation Of Lipid Kinase Activity	Protein Phosphorylation Protein Targeting To Vacuole Phosphatidylinositol Biosynthetic Process Macroautophagy Autophagy Of Peroxisome Regulation Of Cytokinesis Receptor Catabolic Process Toll-like Receptor 9 Signaling Pathway Cellular Response To Glucose Starvation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Late Endosome To Vacuole Transport
Pathways			PI3K Cascade Macroautophagy Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Toll Like Receptor 9 (TLR9) Cascade RHO GTPases Activate NADPH Oxidases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 24026423) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell count ( 32888494) Schizophrenia ( 28991256 30285260) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Abdominal aortic calcification levels ( 31659325) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: C1orf216 CCNC CDC23 HNF4A IKBKG KDM1A PIK3R4 PPARA PRKAA2 RARA RHOU RPTOR RXRA THRB	6 interacting genes: FNDC3B MAPRE1 NRBF2 PIK3C3 RACK1 YWHAB
Entrez ID		29982	30849
HPRD ID		11401	04010
Ensembl ID		ENSG00000148572	ENSG00000196455
Uniprot IDs		Q96F24	Q99570
PDB IDs		4ZEY
Enriched GO Terms of Interacting Partners?
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