GTF2B and NR2F1

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GTF2B	NR2F1
Description		general transcription factor IIB	nuclear receptor subfamily 2 group F member 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor TFIID Complex Chromosome Nuclear Body Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Transcription Preinitiation Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Complex Binding Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Acetyltransferase Activity TBP-class Protein Binding Thyroid Hormone Receptor Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcriptional Start Site Selection At RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Histone Acetylation Viral Transcription SnRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Core Promoter Binding RNA Polymerase II Core Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Nervous System Development Negative Regulation Of Neuron Projection Development Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Nuclear Receptor transcription pathway
Drugs			beta-Naphthoflavone
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Hematocrit ( 32888494) Intraocular pressure ( 29617998) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 28135244 30578418)	Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		57 interacting genes: ADRB2 ATF4 BCL3 CIITA CREBBP CTBP1 DEPDC7 DHX9 DRAP1 EP300 ESR1 ESRRA FBXO25 FOXF2 GOLGA6L9 GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H4 HMGCL HNF4A HSF1 IKZF1 JAK3 JUN KLF5 MCM2 MECP2 NCOA1 NCOA3 NCOA4 NCOR1 NOLC1 NR1D2 NR2F1 NR5A1 POLR2A POLR2E POU3F2 PSMC2 PSMC5 REL RELA REST SLC22A2 SRA1 TAF11 TAF9 TBP TBPL1 TCEA2 THRA TNIP1 TRAM2 VDR YWHAE	23 interacting genes: AHR BCL11A BCL11B CBX5 COPS2 EEF1D ESR1 GTF2B HNF4A ISL1 MAP6 MCPH1 NCOA1 NCOA2 NCOA3 NCOR2 NSD1 PFDN1 PHB2 POU2F2 RXRA SP1 THRA
Entrez ID		2959	7025
HPRD ID		08928	00584
Ensembl ID		ENSG00000137947	ENSG00000175745
Uniprot IDs		Q00403	P10589
PDB IDs		1C9B 1DL6 1RLY 1RO4 1TFB 1VOL 2PHG 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5WH1 6O9L	2EBL
Enriched GO Terms of Interacting Partners?
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