GSTZ1 and GSS

Data Source:
HPRD (in vitro)

		GSTZ1	GSS
Description		glutathione S-transferase zeta 1	glutathione synthetase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Cytosol Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Maleylacetoacetate Isomerase Activity Identical Protein Binding Protein Homodimerization Activity	Magnesium Ion Binding Glutathione Synthase Activity Protein Binding ATP Binding Glycine Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Glutathione Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process	Cellular Amino Acid Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Nervous System Development Aging Response To Xenobiotic Stimulus Response To Nutrient Levels Response To Tumor Necrosis Factor Response To Amino Acid Response To Cadmium Ion
Pathways		Glutathione conjugation Regulation of pyruvate dehydrogenase (PDH) complex Tyrosine catabolism	Glutathione synthesis and recycling Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione 1,4-Dithiothreitol Dichloroacetic acid Glycerin	Glutathione Glycine Cysteine gamma-Glutamylcysteine Phosphoaminophosphonic Acid-Adenylate Ester Acetylcysteine Copper
Diseases			Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS			Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) Height ( 28552196) Hemostatic factors and hematological phenotypes ( 22443383) QRS complex (Cornell) ( 27659466) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: CLVS2 GORASP2 GSS PLEKHG4 PPP1CC QARS1 TCP11 TRAF2 ZMYND12	2 interacting genes: GSTZ1 TERF1
Entrez ID		2954	2937
HPRD ID		04785	03000
Ensembl ID		ENSG00000100577	ENSG00000100983
Uniprot IDs		A0A0A0MR33 A0A0C4DFM0 O43708	P48637 V9HWJ1
PDB IDs		1FW1	2HGS
Enriched GO Terms of Interacting Partners?
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