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GSTM1 and MAP3K5
Data Source:
HPRD
(in vitro, in vivo)
GSTM1
MAP3K5
Description
glutathione S-transferase mu 1
mitogen-activated protein kinase kinase kinase 5
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Intercellular Bridge
Cytoplasm
Cytosol
External Side Of Plasma Membrane
Protein-containing Complex
Protein Kinase Complex
IRE1-TRAF2-ASK1 Complex
Molecular Function
Glutathione Transferase Activity
Enzyme Binding
Protein Homodimerization Activity
Glutathione Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Prostaglandin Metabolic Process
Glutathione Metabolic Process
Nitrobenzene Metabolic Process
Xenobiotic Catabolic Process
Hepoxilin Biosynthetic Process
Cellular Detoxification Of Nitrogen Compound
Glutathione Derivative Biosynthetic Process
MAPK Cascade
Activation Of MAPKK Activity
Response To Ischemia
Protein Phosphorylation
JNK Cascade
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Viral Process
Cellular Response To Stress
Cellular Response To Amino Acid Starvation
Response To Endoplasmic Reticulum Stress
P38MAPK Cascade
Wound Healing
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Stress-activated MAPK Cascade
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Hydrogen Peroxide
Cellular Response To Tumor Necrosis Factor
Endothelial Cell Apoptotic Process
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Neuron Death
Cellular Response To Reactive Nitrogen Species
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
Glutathione conjugation
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
Drugs
Glutathione
Chloroquine
(9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene
Zinc trihydroxide
S-(2,4-dinitrophenyl)glutathione
Glutathione disulfide
5-fluorotryptophan
(9S,10S)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene
Diseases
GWAS
Bladder cancer (
20972438
)
Blood protein levels (
30072576
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
32888494
)
Eosinophil counts (
32888494
)
HDL cholesterol (
30275531
)
HDL cholesterol levels (
32203549
)
Immature fraction of reticulocytes (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
3 interacting genes:
GSTM2
GSTM3
MAP3K5
64 interacting genes:
AKT1
ARRB1
ARRB2
AURKA
CCND2
CDC25A
CDK4
CDK6
CDKN1A
CDKN2A
CREBBP
DAB2IP
DAXX
DMD
DUSP19
EIF2AK2
EP300
ERN1
FGFR4
FZR1
GADD45B
GEMIN5
GLIS2
GLRX
GSTM1
HSPA1A
IGF1R
JAK2
MAP2K4
MAP2K6
MAP2K7
MAP3K2
MAP3K3
MAP3K6
MAP3K7
MAPK8IP3
MBP
NEDD4
NEDD4L
NF2
PDCD6
PPP3R1
PPP5C
PTPN11
QARS1
RAF1
SFN
SIAH1
STK11
TEAD2
TERT
TNFAIP3
TNNT2
TPD52L1
TRAF2
TRAF5
TRAF6
TULP3
TXN
USP9X
YWHAE
YWHAH
YWHAQ
YWHAZ
Entrez ID
2944
4217
HPRD ID
00707
03904
Ensembl ID
ENSG00000134184
ENSG00000197442
Uniprot IDs
P09488
X5D932
X5DR03
Q99683
PDB IDs
1GTU
1XW6
1XWK
1YJ6
2F3M
2CLQ
3VW6
4BF2
4BHN
4BIB
4BIC
4BID
4BIE
5ULM
5UOR
5UOX
5UP3
5V19
5V24
5VIL
5VIO
6E2M
6E2N
6E2O
6EJL
6OYT
6OYW
6VRE
6XIH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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