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TBK1 and CDC42BPG
Data Source:
BioGRID
(affinity chromatography technology, pull down)
TBK1
CDC42BPG
Description
TANK binding kinase 1
CDC42 binding protein kinase gamma
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Endosome Membrane
Intracellular Membrane-bounded Organelle
Cytoplasm
Cytosol
Cytoskeleton
Cell Leading Edge
Centriolar Satellite
Molecular Function
Nucleic Acid Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Identical Protein Binding
Phosphoprotein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Activation Of Innate Immune Response
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Response To Virus
Viral Process
Positive Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Type I Interferon Production
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Peptidyl-serine Phosphorylation
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Dendritic Cell Proliferation
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Defense Response To Gram-positive Bacterium
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Regulation Of Neuron Death
Positive Regulation Of Xenophagy
Protein Phosphorylation
Peptidyl-threonine Phosphorylation
Actomyosin Structure Organization
Actin Cytoskeleton Reorganization
Intracellular Signal Transduction
Pathways
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
Regulation of innate immune responses to cytosolic DNA
STAT6-mediated induction of chemokines
IRF3-mediated induction of type I IFN
Interleukin-37 signaling
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Potential therapeutics for SARS
Drugs
Fostamatinib
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (
29566793
27455348
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lung adenocarcinoma (
28604730
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Gout (combined type) (
32238385
)
Serum uric acid levels (
29124443
)
Urate levels (
21768215
)
Interacting Genes
44 interacting genes:
AGO2
APP
ATG9A
AZI2
CALCOCO2
CDC37
CDC42BPG
CYLD
HSP90AA1
HSP90AB1
IKBKB
IKBKG
IRF3
IRF5
IRF7
MAP1LC3B
MAVS
MBP
MIB2
MTPAP
NCK1
NEDD4
NFKBIA
PROS1
PTPRD
RELA
RIPK1
RNF128
RPS6KB1
SIKE1
SMCR8
SMURF1
SQSTM1
STX11
TANK
TICAM1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRIM21
TRIM27
TXLNG
XIAP
4 interacting genes:
CDC42
RAC1
RHOQ
TBK1
Entrez ID
29110
55561
HPRD ID
05322
13013
Ensembl ID
ENSG00000183735
ENSG00000171219
Uniprot IDs
Q9UHD2
Q6DT37
PDB IDs
4EFO
4EUT
4EUU
4IM0
4IM2
4IM3
4IW0
4IWO
4IWP
4IWQ
5EOA
5EOF
5EP6
5W5V
6BNY
6BOD
6BOE
6CQ0
6CQ4
6CQ5
6NT9
6O8B
6RSR
6RST
6RSU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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